大鼠大脑中动脉缺血/再灌注时间窗  

Time window of ischemia/reperfusion of middle cerebral artery in rats

作　　者：刘立[1] 周永清[1] 

机构地区：[1]第四军医大学航空航天医学系航空临床医学教研室,陕西西安710033

出　　处：《医学争鸣》2001年第S1期1-2,共2页Negative

基　　金：国家自然科学基金项目 ( 39170 315);全军医药卫生科研基金项目 ( 92 50 52 )

摘　　要：目的　了解局灶性脑缺血时间与梗死范围之间的关系 ,为脑缺血的溶栓治疗提供实验数据 .方法　采用大鼠大脑中动脉缺血模型 ,在该模型造成不同时间的大脑中动脉缺血 /再灌注时间 ,应用图像分析测算梗死面积 .结果　缺血 4 h以内梗死范围随着缺血时间增大 ;缺血 4 h/再灌注 2 0 h组与缺血 2 4 h组的梗死范围之间无明显差别 .结论　局灶性脑缺血有再灌注时间窗 。AIM To investigate the relationship between time of cerebral ischemia and extent of infarct area. METHODS The rat model of middle cerebral artery (MCA) ischemia was used for evaluate time of cerebral ischemia/reperfusion and the infarct sizes were analyzed with image analysis system. RESULTS The infarct size increased with increasing MCA occlusion time, up to 4 h, when the infarct size as extensive as those observed following 24 h permanent MCA occlusion. CONCLUSION Reperfusion beyond the time window of cerebral ischemia can not reduce infarct size.

关 键 词：脑缺血 再灌注 大鼠 

分 类 号：R743.3[医药卫生—神经病学与精神病学]