中枢抑制对大鼠局灶性脑缺血后运动功能代偿的再探  

Evaluation of motor functional compensation after the focal cerebral ischemia in rats

作　　者：周永清[1] 刘立[1] 

机构地区：[1]第四军医大学航空航天医学系航空临床医学教研室,陕西西安710033

出　　处：《医学争鸣》2001年第S1期6-9,共4页Negative

摘　　要：目的　研究大鼠局灶性脑缺血后 ,梗死部位及相关脑区的功能代偿与运动行为恢复的关系 .方法　线栓法建立大鼠的大脑中动脉缺血模型 (MCAO) ;于再灌注后不同时间点 ,采用运动功能神经症状检测法评估大鼠的运动功能恢复程度与时间的关系 ;采用 846合剂 (速眠新注射液 )小剂量缓慢腹腔注射抑制中枢神经系统的方法 (意识未完全丧失 ) ,评价运动功能恢复与梗死部位的功能恢复和相关脑区的功能代偿的关系 .结果　在缺血后 2 wk内 ,前肢的运动功能获得明显的恢复 ,4wk以后 ,完全恢复正常 ;大鼠缺血 72 h后、4wk内各期之间感觉运动神经症状评分均有明显的统计学差异(P<0 .0 1 ) ,而 4wk后各阶段的感觉运动神经症状评分无统计学差异 (P>0 .0 5) ;在中枢抑制条件下 ,大鼠的前肢梗死偏瘫症状又显现出来 ,且与缺血初期的偏瘫积分无明显的差异 ,抑制解除后 ,偏瘫症状又消失 .结论　大鼠缺血 /再灌注损伤后 4 wk内是运动功能完全恢复的关键阶段 ,中枢抑制可使这种功能代偿作用完全消除 .皮层梗死区的功能并不能恢复到损伤之前的程度 。AIM To study interrelation between motor behavioral recovery and functional compensation of the infarctdistrict and correlated districts after focal ischemia in rats. METHODS Unilateral cerebral ischemia was induced in rats by the middle cerebral artery occlusion (MCAO); Forelimbs motor function was evaluated with measure standard of motor function test; To evaluate interrelation between recovery and the distincts of functional compensation after the CNS was restrained by using 846 Mixture. RESULTS Forelimbs motor function has recovered completely at 4 wk after the forcal cerebral ichemia. Motor symptom grade demonstrated statistically significant increased between 1, 3 d and 1, 2, 4 wk. Hemiplegia symptom disappeared after the central inhibition but showed up again after disinhibition. CONCLUSION The key phase of function compensation was 4 wk after the forcal cerebral ischemia in rats, functional compensation was relieved completely by disinhibition; Not only cortical ischemia position but also other brain distincts besides ischemia position was related to behavioral function recovery, but the latter was more important.

关 键 词：局灶性脑缺血 运动功能 中枢抑制 大鼠 

分 类 号：R743.3[医药卫生—神经病学与精神病学]