联合应用速避凝与阿司匹林治疗急性缺血性脑卒中临床研究  

Clinical Studies on Fraxiparine Associated with Aspirin Treating Acute Ischemic Stroke

作　　者：孙顺昌[1] 陈宪琪[1] 

机构地区：[1]青岛市第八人民医院,266100

出　　处：《青岛医药卫生》2001年第3期176-178,共3页Qingdao Medical Journal

摘　　要：目的 研究速避凝与阿司匹林联合应用防治脑梗死的疗效,以及对凝血功能的影响和继发性脑出血的发生率。方法 应用速避凝配伍司匹林静滴及单用速避凝治疗发病24h以内的急性脑梗死病人125例。采取随机分组对照临床研究。在应用速避凝配伍阿司匹林治疗前及用药后第14天分别进行神经功能缺损评分(NDF),在病人出院时和第12周进行两次病人日常生活能力评估(Barthel氏指数)。同时于治疗前、后检测凝血功能、脑出血并发率及肝功、肾功并与对照组比较。结果 治疗组凝血酶原活动度(A)在用药后显著降低(P<0.05),近期疗效,第14天神经功能缺损评分及出院时Barthel氏指数,治疗组较对照组有显著进步(P<0.05)。对肝功、肾功无影响。结论 速避凝配伍阿司匹林比单独应用阿司匹林治疗急性缺血性脑卒中疗效更好。Objective In order to study the effective evaluation of Fraxiparine treating acute cerebral ischemic stroke by concomitant use of Aspirin and to study the effect on coagulated function and the risk of ischemic area bleeding. Methods 64 patients were treated with Fraxiparine and Aspirin, 61 patients with Aspirin only by random grouping. The nerve function deficit score was evaluated before and the 14th day after drug therapy, the routine life ability (Barthel index) was evaluated at the time of discharged and the 12th week. Before and after the therapy, coagualated function, and risk of infarcted area bleeding and nephritic function were tested. Results The prothrombin activety (A) of the patients was decreased more significantly after treated with Fraxiparine and Apirin(P<0. 05), but the risk of infarcted area bleeding was not increased by statistic analysis . The nerve function deficit score at the time of the 14th day and the Barthel index at the time of discharged with Fraxiparine and Aspirin improved much more than those of the control group (P<0. 05). Conclusion Fraxiparine associated with Aspirin treating acute cerebral ischemic stroke has better effect than use Aspirin only.

关 键 词：脑梗死 速避凝 阿司匹林 

分 类 号：R743.3[医药卫生—神经病学与精神病学]