Relationship between the Expression of α1-Antitrypsinase in Bronchioalveolar Carcinoma and Clinical Pathology  

作　　者：吴翠环 陈春莲 杨毅 郝春荣 倪娟 车东媛 

出　　处：《Journal of Huazhong University of Science and Technology(Medical Sciences)》2000年第1期26-28,共3页华中科技大学学报（医学英德文版）

摘　　要：Summary: By using immunohistochemistry LSAB method and imaging analysis technique, the ex- pression of al-antitrypsinase (α1-AT) in 41 cases of bronchioalveolar carcinoma (BAC) was quan- titatively detected to explore the relationship between α1-AT expression in BAC tissues and clinical pathology. The results showed that the total positive rate for α1-AT expression was 85. 4 %. The positive rate for α1-AT expression in alveolar BAC was 100 %, with the immunity reactive stain- ing intensity being significantly higher than in papillary BAC, mucinous BAC or sclerosing BAC (P<0. 05). The positive rate in papillary BAC was 93. 3 %, with the intensity higher mucinous BAC or sclerosing BAC (P<0. 01); The positive rate in both mucinous BAC and sclerosing BAC was 66. 7 % (P>0. 05); The expression intensity in lymph node metastatic group was obviously lower than that in the group without metastasis (P<0.01); The patients with mucinous BAC were diagnosed at a younger age than those with other histologic types of BAC (P<0. 05). It was suggested that BAC cells could also produce al-AT. Detection of α1-AT could be used as a new method to diagnose BAC and might play a role in assessing BAC metastasis.Summary: By using immunohistochemistry LSAB method and imaging analysis technique, the ex- pression of al-antitrypsinase (α1-AT) in 41 cases of bronchioalveolar carcinoma (BAC) was quan- titatively detected to explore the relationship between α1-AT expression in BAC tissues and clinical pathology. The results showed that the total positive rate for α1-AT expression was 85. 4 %. The positive rate for α1-AT expression in alveolar BAC was 100 %, with the immunity reactive stain- ing intensity being significantly higher than in papillary BAC, mucinous BAC or sclerosing BAC (P<0. 05). The positive rate in papillary BAC was 93. 3 %, with the intensity higher mucinous BAC or sclerosing BAC (P<0. 01); The positive rate in both mucinous BAC and sclerosing BAC was 66. 7 % (P>0. 05); The expression intensity in lymph node metastatic group was obviously lower than that in the group without metastasis (P<0.01); The patients with mucinous BAC were diagnosed at a younger age than those with other histologic types of BAC (P<0. 05). It was suggested that BAC cells could also produce al-AT. Detection of α1-AT could be used as a new method to diagnose BAC and might play a role in assessing BAC metastasis.

关 键 词：bronchioalveolar carcinoma α1-antitrypsinase IMMUNOHISTOCHEMISTRY imaging analysis 

分 类 号：R734[医药卫生—肿瘤]