Effect of Cardiopulmonary Bypass on Beta Adrenergic Receptor Adenylate Cyclase System on Surfaces of Peripheral Lymphocytes  

作　　者：罗爱林 田玉科 金士翱 

出　　处：《Journal of Huazhong University of Science and Technology(Medical Sciences)》2000年第1期77-78,共2页华中科技大学学报（医学英德文版）

摘　　要：Summary: The experimental results showed that the level of CAMP, the ratio of cAPM to cGMP, IL-2R expression and IL-2 production in vitro in lymphocytes immediate and 2 weeks after car- diopulmonary bypass (CPB) were significantly lower than those before anesthetics in the patients undergoing cardiac surgery with CPB. These findings suggested that CPB could cause serious damage to adrenergic beta receptor-adenylate cyclase system on circulating lymphocytes surfaces, which might be one of the mechanisms resulting in immunosuppression after open heart surgery with CPB.Summary: The experimental results showed that the level of CAMP, the ratio of cAPM to cGMP, IL-2R expression and IL-2 production in vitro in lymphocytes immediate and 2 weeks after car- diopulmonary bypass (CPB) were significantly lower than those before anesthetics in the patients undergoing cardiac surgery with CPB. These findings suggested that CPB could cause serious damage to adrenergic beta receptor-adenylate cyclase system on circulating lymphocytes surfaces, which might be one of the mechanisms resulting in immunosuppression after open heart surgery with CPB.

关 键 词：cardiopulmonary bypass adrenergic beta receptor-adenylate cyclase cellular  immunity 

分 类 号：R363[医药卫生—病理学]