Synthesis of O -Phosphorylated Oligopeptides Using Phosphoramidite  

作　　者：李艳梅 赵玉芬 

出　　处：《Tsinghua Science and Technology》2000年第2期163-166,共4页清华大学学报（自然科学版（英文版）

基　　金：the National Natural Science Foundationof China! ( No.2 980 2 0 0 6) ;Chao Guangbiao High-Tech Fund!( No.97JC0 5 9

摘　　要：Reversible protein phosphorylation is of great importance in the regulation of many cellular processes. Structurally well defined compounds are needed for the study of the roles of the phospho proteins in biological processes. In this paper, O phosphorylated oligopeptides were synthesized using bis alkyloxy N,N dialkylphosphoramidite reacting with the oligopeptide followed by oxidation. Many hydroxyl groups in oligopeptides can be phosphorylated in one step.Reversible protein phosphorylation is of great importance in the regulation of many cellular processes. Structurally well defined compounds are needed for the study of the roles of the phospho proteins in biological processes. In this paper, O phosphorylated oligopeptides were synthesized using bis alkyloxy N,N dialkylphosphoramidite reacting with the oligopeptide followed by oxidation. Many hydroxyl groups in oligopeptides can be phosphorylated in one step.

关 键 词：phosphorylated oligopeptide PHOSPHORAMIDITE OXIDATION SYNTHESIS 

分 类 号：TQ93[化学工程]