Clinical significance of changes in β-adrenoreceptors in peripheral lymphocytes in patients with essential hypertension  

作　　者：彭应心 马淑平 张树军 李玉龙 杨丽明 边树怀 

出　　处：《Chinese Medical Journal》2000年第12期8-11,共4页中华医学杂志（英文版）

摘　　要：To explore the relationship of β adrenoreceptor density and function with the condition of patients with essential hypertension Methods In the present study, 69 male patients with essential hypertension at different stages were compared with a group of age matched normotensive controls β adrenoreceptor maximum bound volume (B max ) in peripheral lymphocytes was measured by 3 H dihydroalprenolol ( 3 H DHA) radio ligand binding β adrenoreceptor responsiveness was determined by Salbutamol (injection) Results In patients with essential hypertension at stages Ⅰ and Ⅱ, B max was significantly higher ( P <0 01 and P <0 001, respectively) and the chronotropic doses of Salbutamol required to increase the heart rate by 30 beats/min (CD 30 ) were significantly lower ( P <0 01 and P <0 001, respectively) than in age matched normotensive control subjects In patients with essential hypertension at stage Ⅲ, B max was significantly lower and CD 30 was significantly higher (both P <0 01) than those in the age matched normotensive control subjects B max was significantly higher and CD 30 was significantly lower (both P <0 001) in patients with essential hypertension and with left ventricular hypertrophy (LVH) than that in patients with essential hypertension but without LVH In patients with essential hypertension and heart failure, B max was significantly lower and CD 30 was significantly higher (both P <0 001) than those in patients with essential hypertension without heart failure Conclusions The changes of β adrenoreceptor density and function were related to hypertension, hypertension complicated with ventricular hypertrophy, and heart failure They may be viewed as indexes of the condition in the patients with essential hypertensionTo explore the relationship of β adrenoreceptor density and function with the condition of patients with essential hypertension Methods In the present study, 69 male patients with essential hypertension at different stages were compared with a group of age matched normotensive controls β adrenoreceptor maximum bound volume (B max ) in peripheral lymphocytes was measured by 3 H dihydroalprenolol ( 3 H DHA) radio ligand binding β adrenoreceptor responsiveness was determined by Salbutamol (injection) Results In patients with essential hypertension at stages Ⅰ and Ⅱ, B max was significantly higher ( P <0 01 and P <0 001, respectively) and the chronotropic doses of Salbutamol required to increase the heart rate by 30 beats/min (CD 30 ) were significantly lower ( P <0 01 and P <0 001, respectively) than in age matched normotensive control subjects In patients with essential hypertension at stage Ⅲ, B max was significantly lower and CD 30 was significantly higher (both P <0 01) than those in the age matched normotensive control subjects B max was significantly higher and CD 30 was significantly lower (both P <0 001) in patients with essential hypertension and with left ventricular hypertrophy (LVH) than that in patients with essential hypertension but without LVH In patients with essential hypertension and heart failure, B max was significantly lower and CD 30 was significantly higher (both P <0 001) than those in patients with essential hypertension without heart failure Conclusions The changes of β adrenoreceptor density and function were related to hypertension, hypertension complicated with ventricular hypertrophy, and heart failure They may be viewed as indexes of the condition in the patients with essential hypertension

关 键 词：hypertension  · β adrenoreceptor · ADRENERGIC 

分 类 号：R544.1[医药卫生—心血管疾病]