Effect of anti-P-selectin monoclonal antibody on renal ischemia/reperfusion injury in rats  

作　　者：周同 李晓 吴佩 张东华 张明钧 陈楠 董德长 

机构地区：[1]Department of Nephrology,Ruijin Hospital,Shanghai Second Medical University

出　　处：《Chinese Medical Journal》2000年第9期22-25,共4页中华医学杂志（英文版）

基　　金：ThisworkwassupportedbytheScientificFoundationofMinistryofHealthofChina (No 98 2 2 83)andShanghaiNaturalScienceFoundation (N

摘　　要：To explore the effect of anti-P-selectin monoclonal antibody (mAb) on renal ischemia/reperfusion (I/R) injury in rats Methods Renal function, renal histopathological changes, plasma P-selectin levels and renal P-selectin protein and mRNA expression were studied in a renal I/R injury rat models Biochemical measurement, ELISA, Immunohistochemistry and Nested RT-PCR were used Results Renal function insufficiency and renal histopathological damage were much less in the anti-P-selectin mAb-treated group than the saline-treated group Plasma P-selectin levels were lower and renal P-selectin protein and mRNA expression were down-regulated in the former group Conclusion Anti-P-selectin mAb might be an efficient approach for the treatment of renal I/R injuryTo explore the effect of anti-P-selectin monoclonal antibody (mAb) on renal ischemia/reperfusion (I/R) injury in rats Methods Renal function, renal histopathological changes, plasma P-selectin levels and renal P-selectin protein and mRNA expression were studied in a renal I/R injury rat models Biochemical measurement, ELISA, Immunohistochemistry and Nested RT-PCR were used Results Renal function insufficiency and renal histopathological damage were much less in the anti-P-selectin mAb-treated group than the saline-treated group Plasma P-selectin levels were lower and renal P-selectin protein and mRNA expression were down-regulated in the former group Conclusion Anti-P-selectin mAb might be an efficient approach for the treatment of renal I/R injury

关 键 词：P-SELECTIN · monoclonal antibody  · ischemia/reperfusion injury  · RAT 

分 类 号：R692[医药卫生—泌尿科学]