Comparative study of D_2 receptors and dopamine content in striatum before and aftere lectro- acupuncture treatment in rats  

作　　者：林岩松 林祥通 

出　　处：《Chinese Medical Journal》2000年第5期24-27,共4页中华医学杂志（英文版）

摘　　要：To evaluate the change in D 2 receptors and their relationship with dopamine (DA) content in experimental hemi parkinsonism rats before and after electro acupuncture (EA) treatment Methods 125 Ⅰ IBZM D 2 receptor cerebral autoradio^graphic analysis, HPLC ECD detection of DA and its metabolites, homovanillic acid (HVA), 3,4 dihydroxyphenylacetic acid (DOPAC) were used to study their levels in striatum in pre EA, EA and EA control group Results The DA, HVA and DOPAC levels in striatum of the lesioned side in the EA group were elevated compared to the pre EA and EA control group ( P <0 05) For the EA group, the striatum/cerebellum 125 Ⅰ IBZM uptake ratio of the lesioned side was 8 04±0 71, (29 34%±4 83%) more than that of the contralateral side ( P <0 05), while no significant difference was observed as compared with that in the pre EA group (8 09±0 52, 30 12%±4 53%, higher than that of the intact side P >0 05) It was lower than the EA control group (8 61±0 63, P <0 05), and the latter was (38 63%±3 71%) higher than that in its contralateral side ( P <0 05) Conclusion 6 OH DA lesions in the substantia nigra and ventral tegmental areas induce an up regulation of striatal D 2 binding sites EA treatment could elevate the DA level of the lesioned side striatum and prevent D 2 receptor up regulation in rats with experimental hemi parkinsonismTo evaluate the change in D 2 receptors and their relationship with dopamine (DA) content in experimental hemi parkinsonism rats before and after electro acupuncture (EA) treatment Methods 125 Ⅰ IBZM D 2 receptor cerebral autoradio^graphic analysis, HPLC ECD detection of DA and its metabolites, homovanillic acid (HVA), 3,4 dihydroxyphenylacetic acid (DOPAC) were used to study their levels in striatum in pre EA, EA and EA control group Results The DA, HVA and DOPAC levels in striatum of the lesioned side in the EA group were elevated compared to the pre EA and EA control group ( P <0 05) For the EA group, the striatum/cerebellum 125 Ⅰ IBZM uptake ratio of the lesioned side was 8 04±0 71, (29 34%±4 83%) more than that of the contralateral side ( P <0 05), while no significant difference was observed as compared with that in the pre EA group (8 09±0 52, 30 12%±4 53%, higher than that of the intact side P >0 05) It was lower than the EA control group (8 61±0 63, P <0 05), and the latter was (38 63%±3 71%) higher than that in its contralateral side ( P <0 05) Conclusion 6 OH DA lesions in the substantia nigra and ventral tegmental areas induce an up regulation of striatal D 2 binding sites EA treatment could elevate the DA level of the lesioned side striatum and prevent D 2 receptor up regulation in rats with experimental hemi parkinsonism

关 键 词：Parkinson's disease ANIMALS laboratory RECEPTORS DOPAMINE acupuncture therapy corpus striatum 

分 类 号：R96[医药卫生—药理学]