乳腺癌患者血清CA15-3的检测及临床意义  

Detection of plasma levels of CA15 3 and discussion of their clinical significance in breast cancer patients

作　　者：张铭[1] 

机构地区：[1]南京军区南京总医院解放军普通外科研究所

出　　处：《医学研究生学报》1999年第1期11-13,共3页Journal of Medical Postgraduates

摘　　要：目的：探讨肿瘤相关抗原ＣＡ１５－３水平和阳性率与肿瘤复发、转移等预后因素的关系。方法：选择６０例不同病理类型乳腺癌患者作前瞻性研究，并采用免疫放射分析法（ＩＲＭＡ）进行检测ＣＡ１５－３水平。结果：发现不同淋巴结及远处癌转移状况、不同的乳腺癌患者血清ＣＡ１５－３水平及其阳性率差异显著（Ｐ＜０．０５）。对患者术后随访期间ＣＡ１５－３动态观察发现，术后较术前有所下降，局部或对侧复发者较无瘤生存者明显升高，对手术治疗的彻底性也有一定指导意义。结论：对乳腺癌患者尤其是在术后定期检测血清ＣＡ１５－３水平变化，可作为监测复发和转移等的一项有价值的指标。Objectives:To study the relationship between the plasma levels and positive rates of cancer antigen CA15 3 and tumour prognosis factors. Methods:Sixty breast cancer patients with various clinical phases and patologic types were selected and made prospective study,whose plasma levels of CA15 3 were detected routinely by IRMA. Results:We found that there were significant differences of CA15 3 in those patients who hade carcinoma metastasis to different lymph nodes and remote orgnas.During post operation period,the trending observations of them showed that there also were more visible decreases of CA15 3 than that of pre operation and sharper increases of CA15 3 in local and another side breast reoccurrences patients than that in suvvivals. conclusions:We suggest that the plasma levels of CA15 3 should be measured periodically as a more valueable means of mornitoring of local reoccurrence and remote metastasis for all breast cancer patients especially in the post operation times.

关 键 词：乳腺癌 肿瘤相关抗原 CA15-3 

分 类 号：R737.9[医药卫生—肿瘤]