PCNA表达与原发性肝癌生物学行为及预后关系  

The relationship between the PCNA expression and the biological behaviour and the prognosis of primary hepatocelular carcinoma.

作　　者：方伟召[1] 王广田[1] 王毅[1] 胡建设 孙培春[1] 吉庆明[3] 

机构地区：[1]河南医科大学二附院,450003 [2]禹州市公疗医院 [3]河南省胸科医院

出　　处：《河南外科学杂志》1999年第1期1-3,共3页Henan Journal of Surgery

摘　　要：目的:探讨增殖细胞核抗原(proliferating cell nuclear antigen,PCNA)表达与肝细胞性肝癌(hepatocellular carcinoma,HCC)生物学行为及临床预后的关系。方法:用免疫组织化学方法检测59例HCC癌组织和40例癌旁肝组织中PCNA的表达情况。结果:59例癌组织的PCNA标记指数(Labelling index,LI)(41.9％±21.8％)显著高于40例癌旁肝组织(1.9％±1.0％)(P<0.001)。分化程度Ⅰ、Ⅱ、Ⅲ、Ⅳ级的癌组织其平均PCNA LI分别为14.6％±3.5％、26.7％±6.9％、50.4％±16.7％和72.7％±14.7％,经统计学分析,PCNA LI与肝癌组织的组织学分级有显著相关性(P值均小于0.005)。高PCNALI组(≥42％)与低PCNA LI组(<42％)相比,前组的肿瘤包膜浸润率(91.7％)和静脉癌栓形成率(83.3％)显著高于后组(分别为45.0％和42.9％)(P值均小于0.05)。术后存活期<5年组的PCNA LI(59.3％±15.6％)显著高于术后存活期≥15年组(32.7％±9.8％)(P<0.001)。结论:测定PCNA LI对于判定HCC组织学分化程度、评估其生物学行为、判断HCC患者预后具有一定意义。Objective To study the proliferating cell nuclear antigen( PCNA) expression and the biological behavior and clinical prognosis of primary hepatoeollular carcinoma (HCC) .Methods PCNA was detected in 59 HCC species and 40 adjacent hepatic tissues (AHT) with immunohistoche-mical method. Results The PCNA labelling index (LI) in 59 HCC tissues (41.9%±21.8%) was significantly higher than that in 40 AHT (1.9% ± 1.0%)(P < 0.001) .The average PCNA U in grade Ⅰ ,Ⅱ ,Ⅲ and Ⅳ of HCC tissues were 14.6% ±3.5% ,26.7% ± 6.9% ,50.4%± 16. 7% and 72.7 % ± 14.7% resprctively. There was a significant relationship between the PCNA LI and the histological grades of HCC ( P < 0.00 5). The high PNCA LI group (≥42%) was significantly higher in rate of capsular invasion (91.7%) and of formation of venous cancer embolus (83. 3%) than the low PCNA LI group ( <42%)(45.0% adn42.9% respectively )(P< 0.05) .The PCNA LI in the patients surviving <5 years after operation (59.3% ± 15.6%) was markedly higher than that in the patients surviving ≥5 years after operation (32.7% ± 9.8%)( P < 0.001). Conclusion Determination of PCNA LI is useful to grade the HCC, to evaluate the biological behavior of HCC and to predict the prognosis of the HCC patients.

关 键 词：增殖细胞核抗原 肝细胞性肝癌 免疫组织化学 预后 

分 类 号：R735.7[医药卫生—肿瘤]