胃腺癌发生发展过程中Fas的表达  

6 Alteration of Fas protein expression in the Carcinogenesis of gastric adenocarcinoma

作　　者：贾百灵[1,2] 李修玲[1,2] 周炳喜[1,2] 李继昌[1,2] 黄河[1,2] 王宇航[1,2] 

机构地区：[1]河南省人民医院 [2]河南医科大学第一附属医院

出　　处：《中国民康医学》1999年第3期24-26,65,共4页Medical Journal of Chinese People’s Health

摘　　要：目的：探讨Ｆａｓ基因在胃癌发生发展中的意义。方法：用免疫组织化学方法检测了４８例胃腺癌组织及７４例非癌胃粘膜组织中的Ｆａｓ蛋白。结果：发现不典型增生组织中及癌组织中的Ｆａｓ蛋白表达较正常上皮明显下降（Ｐ＜０．０５），有淋巴结转移者Ｆａｓ表达率低于无淋巴结转移者（Ｐ＜０．０５），浸润愈深，Ｆａｓ表达率越低。随癌分化程度下降，Ｆａｓ蛋白阳性率呈下降趋势。低分化者阳性率显著低于中、高分化者（Ｐ＜０．０５）。结论：Ｆａｓ蛋白表达的变化是胃腺癌发生的早期事件，并可能与癌的进展及预后密切相关。Objective:Aim To study the role of Fas gene in the carcinogenesis of gastric adenocarcinoma the expression of Fas protein in the cancer tissues from 48 patients and nocancer tissues from 74 patients were detected with immunohistochemical method.Methods:Immunohistochemical method.Result:The expression of Fas protein in dysplasia and cancer tissue decreased significantly as compared to that in the mormal epithelia( P <0.05),the positive rates of Fas protein in cancers of grade Ⅰ,Ⅱ and Ⅲ decresed gradually.The cancer of grade Ⅲ showed a significant lower expression of Fas protein than cancer of grade Ⅰ and Ⅱ( P <0.05).Conclusions:The alteration of Fas gene is an early event in the carcinogenesis of stomach cancer and may be closely related to the progress and prognosis of the cancer. [

关 键 词：FAS蛋白 胃癌 癌变机制 免疫组化 

分 类 号：R735.204[医药卫生—肿瘤]