Enthalpy-entropy compensation effect in gas chromatographic enantiomeric separation  

作　　者：周良模 聂孟言 王清海 朱道乾 申河清 

机构地区：[1]Dalian Institute of Chemical Physics , Chinese Academy of Sciences, Dalian, Liaoning 116012, China

出　　处：《Chinese Journal of Chemistry》1999年第4期363-376,2,共14页中国化学（英文版）

基　　金：Project (No.29775025) supported by the National Natural Science Foundation of China.

摘　　要：In this paper, the enthalpy-entropy compensation effect in the enantiomeric separation by modified cyclodextrins (CD) and diamide chiral stationary phase (GP) gas chromatography was investigated using the method of plotting Δ( ΔH) versus Δ(ΔG) 7hm combined with t-test statistic analysis. The investigated racemates cover α-phenylethylamine and its analogs, 2-alkylamines, chiral acyclic alcohols, halogenated arylethanediol-1, 2-diperfluoropropionates, amino acid and its analogs, and two series of compounds containing chloro and bromo substituents. From the compensation analysis results, the effects of the diluent composition in the investigated chiral stationary phases, the size and the died pups on investigated cyclodextrins, the derivatization methods and the groups attached to the stereocenters on enantiomeric separation mechanisms were all discussed.In this paper, the enthalpy-entropy compensation effect in the enantiomeric separation by modified cyclodextrins (CD) and diamide chiral stationary phase (GP) gas chromatography was investigated using the method of plotting Δ( ΔH) versus Δ(ΔG) 7hm combined with t-test statistic analysis. The investigated racemates cover α-phenylethylamine and its analogs, 2-alkylamines, chiral acyclic alcohols, halogenated arylethanediol-1, 2-diperfluoropropionates, amino acid and its analogs, and two series of compounds containing chloro and bromo substituents. From the compensation analysis results, the effects of the diluent composition in the investigated chiral stationary phases, the size and the died pups on investigated cyclodextrins, the derivatization methods and the groups attached to the stereocenters on enantiomeric separation mechanisms were all discussed.

关 键 词：Enthalpy-entropy compensation effect chiral separation GC modified CD-CSP diamide CSP 

分 类 号：O658[理学—分析化学]