肾癌间质微血管定量的临床意义  

The Clinical Significance of Microvessel Quantitation in Renal Cell Carcinoma

作　　者：张晏[1] 葛南[2] 

机构地区：[1]青岛市人民医院,266001 [2]山东医科大学第二附属医院

出　　处：《青岛医药卫生》1999年第4期247-248,共2页Qingdao Medical Journal

摘　　要：目的 研究肾透明细胞癌的微血管与病理分化程度,淋巴结转移和肺转移的关系。方法 应用F-Ⅷ相关抗原免疫组织染色,并用LSAB法对63例手术切除的肾癌组织微血管进行定量分析。结果 随着组织学分级增高,微血管密度增加(P<0.05),微血管密度和腔面积在有无淋巴结转移两组中差别有显著性意义(P<O.01),在有无血行转移两组中差别亦有显著性意义(P<0.05)。结论 微血管与肾癌细胞分化、浸润及淋巴结转移有关,对临床抗微血管治疗有指导意义。Objective To study the relationship of microvessel pathological differentiation, lymph node metastasis,and pulmonary metastasis in renal cell carcinoma. Methods Microvessel quantitation in 63 patients with renal cell carcinoma was analyzed by immunohistochemistry using antibody to factor Ⅷ-related antigen. Results There was much more microvessel quantitation in the higher histological grade(P<0. 05). The count of microvessel and the area of microvessel were significantly different between node-positive and node-negative groups (P<0. 01) , and between the metastasis blood and non-metastasis blood groups (P<0. 05). Conclusion It was suggested that the microvessel was correlated with the tumor cell differentiation,metastasis of lymph node,and metastasis of blood. It was a valuable parameter for clinical treatment against microvessel on patients with carcinoma.

关 键 词：肾细胞癌 微血管定量 转移 

分 类 号：R737.11[医药卫生—肿瘤]