血清fPSA对老年前列腺癌诊断的应用价值  

Study the value of free PSA in the diagnosis of prostate cancer

作　　者：张慕淳[1] 计国义[2] 孔祥波[1] 王伟华[1] 桑原正明 赵雪俭[2] 赵微[1] 

机构地区：[1]吉林大学中日联谊医院泌尿外科,吉林长春130031 [2]吉林大学前列腺疾病防治中心 [3]日本宫城县立癌中心泌尿外科

出　　处：《中国老年学杂志》2004年第6期502-504,共3页Chinese Journal of Gerontology

基　　金：日本政府JICA基金"前列腺癌早期诊断治疗"项目资助

摘　　要：目的　探讨血清游离前列腺特异抗原 (f PSA)及游离 PSA/总前列腺特异抗原 (t PSA)比值对前列腺癌的诊断价值。方法　用酶联免疫方法检测 1 30例前列腺癌 (PCa)、76例前列腺增生 (BPH)以及 42例正常对照组的血清 f PSA、t PSA,并计算 f PSA/ t PSA比值 ,评价其对前列腺癌的诊断价值。结果　以 f PSA/ t PSA比值为 0 .1 5为评判上限时 ,前列腺癌组明显低于前列腺增生组及正常对照组 (P<0 .0 1 ) ,认为 f PSA及 f PSA/t PSA比值可有效区分 PCa和 BPH(P<0 .0 0 5) ,其诊断敏感性为 91 .6% ,特异性为 88.1 % ,准确性为 87.8% ;尤其是当 PSA值界定在 4～ 1 0μg/ L灰区范围内效果更明显优于常规的 t PSA和 f PSA单独测定结果。结论　 f PSA和 f PSA/ t PSA比值的应用 ,使血清 PSA测定更具临床意义 。Objective To investigate the diagnostic value of free prostate specific antigen (fPSA) and fPSA/total prostate specific antigen (tPSA) ratio in prostate cancer Methods Serum fPSA and tPSA were measured in 130 patients with prostate carcinoma, 76 benign prostate hyperplasia (BPH) and 42 healthy subjects by using enzyme linked immunosorbent assay and the ratio of fPSA/tPSA was calculated Results When the upper normal limit of fPSA/tPSA was set at 0 15, it was found that f/t ratio was lower significantly in patients with PCa than that in BPH group and control group The diagnostic sensitivity was 91 6%, the specificity was 88 1% and the accuracy was 87 8%, obviously superior to the results of tPSA or fPSA used alone With the introduction of fPSA and f/t ratio, the early detection of prostate cancer by the assessment of PSA has been made more sensitive and reliable especially when the PSA was within the diagnostic gray zone Conclusions The uses of fPSA and fPSA/tPSA ratio made the test of PSA have more clinical value and enhanced the finding ratio of earlier prostate cancer

关 键 词：前列腺癌 前列腺增生 血清特异抗原 

分 类 号：R737.25[医药卫生—肿瘤]