脑血栓病人血浆内皮素水平24h动态检测  

CIRCADIAN VARIATION OF PLASMA IMMUNOREACTIVB ENDOTHELIN CONCENTRATION IN PATIENTS WITH CERE- BRAL THROMBOSIS

作　　者：李汶霞[1] 李清美[1] 刘成玉[1] 马淑芹[1] 孙建文[1] 于素清[1] 

机构地区：[1]泰山医学院附属医院微循环研究所,青岛医学院附属医院神经科,青岛医学院诊断学教研室,青岛医学院附属医院核医学科

出　　处：《齐鲁医学杂志》1998年第1期7-9,共3页Medical Journal of Qilu

摘　　要：①目的探讨脑血栓急性期病人血浆内皮素（ＥＴ）水平２４ｈ内动态变化规律及其与发病的关系。②方法采用放射免疫测定法测定了３２例脑血栓病人和２０例健康人２：００，８：００，１４：００，２０：００时血浆ＥＴ水平的变化。③结果脑血栓病人昼夜血浆ＥＴ水平明显增高，与对照组比较差异均有极显著性（ｔ＝９．６４－１０．３３，Ｐ均＜０．００１），且在２４ｈ内２：００ＥＴ水平最低，８：００最高，两者比较差异有显著性（ｔ＝３．２２，Ｐ＜０．０ｌ）。有高血压和糖尿病病史的脑血栓病人２４ｈ的ＥＴ水平，均较无高血压、糖尿病病史者显著增高（ｔ＝２．１１－５．１７，Ｐ＜０．０５，０．０１）。④结论脑血栓急性期病人血浆ＥＴ水平２４ｈ内有早晨高和晚上低的节律性变化，其变化与脑血栓发病早晨为高发时间的现象一致。Objective To explore the circadian variation of plasma immunoreactive endothelin level in patienta with acute cerebral thrombosis and its relationship with the onset of the disease. Methods The plasma immunoreactive endothelin level was determined dynamically in 32 patients with cerebral thrombosis (within 3 days) by radioimmunoassy (RIA ) at 2Am. 8Am, 2Pm, 8Pm during 24 hours. Results Plasma ET levels were significantly higher in patients than in controls (t= 9. 64 - 10.33, P < 0. 001). ET level was highest at 8Am, and lowest at 2Am. There was significant difference betweea ET level at two time points (t=3. 22, P<0. 01). ET levels in patients with diabetes mellitus and/or hypertension history were higher than those without dia- beteo mellitus and/or hypertension history (t= 2.11 - 5. 17 , P < 0. 05, 0. 01). Conclusion Plasma ET levels in patients with acute cerebral thrombosis increased significantly and periodic change was presented regularly within 24 hours. Circandian variation of ET level was in accotdance with the time of cerebral thrombosis onset. ET may be one of the important factors leading to cere- bral thrombosis. [

关 键 词：脑血栓 内皮素 昼夜节律 

分 类 号：R743.32[医药卫生—神经病学与精神病学]