核仁组成区嗜银蛋白和肾肿瘤临床关系的研究  

The Relationship Between Argyrophilic Protein of the Nucleolar Organizer Region and Renal Tumours

作　　者：牛天力[1] 俞天麟[1] 张绍增[1] 邢传平[1] 范顺才 刘华福[1] 

机构地区：[1]兰州军区兰州总医院

出　　处：《西北国防医学杂志》1998年第2期23-24,共2页Medical Journal of National Defending Forces in Northwest China

基　　金：甘肃省自然科学基金

摘　　要：目的：探讨核仁组成区嗜银蛋白（ＡｇＮＯＲ）和肾肿瘤的分类、临床分期的关系。方法：用胶体银技术对１１６例肾肿瘤和１１例正常肾组织进行ＡｇＮＯＲ计数并进行分析。结果：ＡｇＮＯＲ计数在肾盂癌、肾细胞癌和Ｗｉｌｍ氏瘤中分别为５．２３±１．４、４．１２±１．２和３．９８±０．９；肾错钩瘤和正常肾组织分别为１．８６±０．９和１．６３±０．７；ＡｇＮＯＲ计数在肾脏良恶性肿瘤之间差异非常显著（Ｐ＜０．０１），肾细胞癌临床Ⅰ、Ⅱ、Ⅲ和Ⅳ期ＡｇＮＯＲ数目分别为３．６５±０．３、４．０２±０．５、４．６２±０．３和４．５８±０．４。结论：ＡｇＮＯＲ计数随肾细胞癌的临床分期升高而增加。Purpose:To explore the relationship between argyrophilic protein of the nucleolar organizer region(AgNOR) and classification,staging of renal tumours. Methods:The silvercolloid tenchnique was used to investigate on 116 patients with renal tumours and 11 normal specimen were used as normal control. Results: The AgNOR counts of renal pelvic epithelial carcinoma, renal cell carcinoma and Wilms tumour were 5.23±1.4,4.12±1.2 and 3.98±0.9 respectively. The AgNOR counts of hamartoma and normal specimen were 1.86±0.9 and 1.63±0.7. AgNOR counts between benign and malignant renal tumours showed significant difference(P<0.01). AgNOR counts of renal cell carcinoma in Ⅰ,Ⅱ,Ⅲ,Ⅳ stage were 3.65±0.3,4.02±0.5,4.62±0.3,4.58±0.4 respectively. Conclusion: AgNOR count is increased in association with higher staging of renal cell carcinoma. AgNOR count could be used as an important reference index to differentiate benign or malignant renal tumour.

关 键 词：肾肿瘤 肿瘤分期 分类 细胞核仁组成区嗜银蛋白(AgNOR) 

分 类 号：R737.11[医药卫生—肿瘤]