The Erythropoietin Receptor: Dimerization and Intracellular Signal Transduction  

作　　者：WU Hong Harvey F Lodish(Whitehead Institute for Biomedical Research, Nine Cambridge Center Cambridge MA 02142 USA) (Department of Biology, Massachusetts Institute of Technology Cambridge MA 02139 USA) 

出　　处：《中国实验血液学杂志》1996年第3期229-235,共7页Journal of Experimental Hematology

摘　　要：Erythropoietin (EPO), a 34 kD glycopro-tein, is the principal growth factor regulating theproduction of circulating erythrocytes; EPO isessential for committed CFU - E erythroid pro-genitors to divide several times and then to dif-ferentiate into erythrocytes. Like most receptorsfor hematopoietic growth factors, the erythro-poietin receptor (EPO - R) is a type I trans-membrane protein and a member of the cytokinereceptor superfamily. These receptors containfour conserved cysteines and a Trp - Ser - X -

关 键 词：ERYTHROPOIETIN ERYTHROPOIETIN RECEPTOR DIMERIZATION SIGNAL TRANSDUCTION 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]