去卵巢大白鼠血浆组织型纤溶酶原激活物与其抑制物的变化  

The Change of Plasma t-PA and PAI Level in Ovariectomy Rats

作　　者：刘国勋[1] 李青南[2] 吴铁[3] 凌光鑫[4] 

机构地区：[1]广东医学院血液病研究室,湛江524001 [2]广东医学院骨生物研究室 [3]广东医学院药理教研室 [4]广东医学院生化教研室

出　　处：《中国实验血液学杂志》1996年第2期188-190,共3页Journal of Experimental Hematology

摘　　要：测定了去卵巢大白鼠血浆组织型纤溶酶原激活物(t-PA)与纤溶酶原激活物抑制物(PAI)水平。与对照组比较去卵巢组血浆t-PA无显著性差异(P>0.05)。对照组PAI为9.7±1.2AU/ml,去卵巢组PAI为7.8±1.9AU/ml,两组比较有显著差异(P<0.05)。去卵巢组血浆中PAI降低,可能与卵巢激素的减少有关。卵巢激素会促使PAI合成并释放增加,这可能是服用雌激素等避孕药者纤溶活性降低、血液呈高凝状态的重要机制之一。The Ievel of tissue-type plasminogen activator(t-PA) and its inhibitor(PAI) in ovariectomy rats were determinated. The results shovved that there were no difference in plasma t-PA activities between the control group ovariectomy group (P>0.05). But, the plasma PAI activities of the control group (9.7 ±1.2 AU/ml) were higher than that of ovariectomy group (7.8± 1.9 AU/ml) CP<0.05). The decrease of the plasma PAI in ovariectomy group was probably re-lated to the ovarian hormone. It was postulated that ovarian hormone can promote the synthe-sis and / or release of PAI, and it is one of the important machanism that the lower fibrinolytic activity and hypercoagulable state were caused by taking the ovarian hormone or contraceptive drugs.

关 键 词：组织型纤溶酶原激活物 纤溶酶原激活物抑制物 去卵巢大鼠 性激素 

分 类 号：R363[医药卫生—病理学]