Effects of Tetrahydroberberine and l─tetrahydropalmatine on^(45)Ca Influx in the Smooth Muscles of Rabbit Thoracic Aorta and Renal Artery  

作　　者：周军 李德兴 

出　　处：《The Journal of Biomedical Research》1996年第1期23-25,29,共4页生物医学研究杂志（英文版）

摘　　要：Thispaperreportstheeffectsoftetrahydroberberine(THB)andl-te-trahydropalmatine(THP)onhighK+-provoked45Cainfluxinrabbitthoracicaorta(TA)andrenalartery(RA).Likeverapamil(Ver),bothTHBandTHP(1,10μmol/L)significantlyinhibitedhighK+-provoked45Cainflux(P<0.01)withoutaf-fectingbasic45CainfluxinTAandRA.Thepotencyorderofthemwasasfolows:Ver>THB>THP.NoapparentlyselectiveresponseinTAandRAwasfoundtoeachdrug.TheseresultsindicatethatTHBandTHPmayhaveblockingeffectonCa2+en-trythroughpotential-dependentchannels.Thispaperreportstheeffectsoftetrahydroberberine(THB)andl-te-trahydropalmatine(THP)onhighK+-provoked45Cainfluxinrabbitthoracicaorta(TA)andrenalartery(RA).Likeverapamil(Ver),bothTHBandTHP(1,10μmol/L)significantlyinhibitedhighK+-provoked45Cainflux(P<0.01)withoutaf-fectingbasic45CainfluxinTAandRA.Thepotencyorderofthemwasasfolows:Ver>THB>THP.NoapparentlyselectiveresponseinTAandRAwasfoundtoeachdrug.TheseresultsindicatethatTHBandTHPmayhaveblockingeffectonCa2+en-trythroughpotential-dependentchannels.

关 键 词：berbines potassiumchloride calciuminflux AORTA renalartery 

分 类 号：R363[医药卫生—病理学]