0,0'-二烷基-α-芳基-α-羟基甲基膦酸酯的合成及其灭螺增效活性的研究  

SYNTHESIS of 0, 0' - DIALKYL-α- ARYL-α-HYDROXYMETHYLPHOSPHONATES AND itsMOLLUSCICIDAL SYNERGISTIC ACTIVITY

作　　者：吴秀琴[1] 戴建荣[2] 王锐[1] 

机构地区：[1]南京药物研究所,南京210009 [2]江苏省血吸虫病防治研究所,南京210038

出　　处：《药学与临床研究》1996年第1期6-9,共4页Pharmaceutical and Clinical Research

摘　　要：合成了12个0,α—二烷基—α—芳基—α—羟基甲基膦酸酯类化合物(Ⅲ_(1-12))。初步杀螺筛选结果表明化合物Ⅲ_(5-8),Ⅲ_(11)具有一定灭螺增效作用。In order to search for potential molluscicidal Syncrgisti , twelve 0, 0'-dialkyl -α-aryl -α-hydroxymethylphos -phonatcs were synthesized- Preliminary biological screening shewed that the compounds Ⅲ5-9,Ⅲ11 combined with 2'5 - dichloro - 4' - nitrosalicylanilidc exhibited some mull seicidal synorgistle activity.

关 键 词：膦酸酯 杀螺剂 增效作用 

分 类 号：R914[医药卫生—药物化学]