恶性肿瘤伴发高钙血症5例  

5 CASES OF CANCER-RELATED HYPERCALCEMIA

作　　者：周美珍[1] 伍健宇[1] 胡亚军[1] 李文举[1] 许佩珉[1] 

机构地区：[1]卫生部北京医院肿瘤内科

出　　处：《中国癌症杂志》1996年第1期24-26,共3页China Oncology

摘　　要：目的及时诊断恶性肿瘤伴发高钙血症的临床意义。方法对经影像学和病理学确诊的５例恶性肿瘤（肺鳞癌３例，乳腺癌１例，肾癌１例）伴发高钙血症进行临床分析。结果４例伴有多发骨转移。５例高钙血症均有不同程度的口渴、多饮、厌食或纳差等胃肠道症状以及疲乏无力、烦燥、表情淡漠或木僵和多尿、便秘、脱水等临床表现，其中２例心电图Ｓ－Ｔ段消失，呈宽大Ｔ波。５例血钙的校正值分别为３．７５ｍｍｏｌ／Ｌ、３．５ｍｍｏｌ／Ｌ、３ｍｍｏｌ／Ｌ、４．４３ｍｍｏｌ／Ｌ、４．５ｍｍｏｌ／Ｌ。经补钠、利尿、骨膦静脉滴注和口服治疗，很快使血钙降至正常。结论对可疑的恶性肿瘤伴发高钙血症患者及时检查，可明确诊断，且经积极治疗后可获好转。PURPOSE To determine the clinical significance of early detection of cancer-related hypercalcemia in malignant neoplasms.METHODS 5 cases of cancer-related hypercalcemia were diagnosed in Beijing Hospital from 1992 to 1995. They were pathologically: lung squamous carcinoma (3),breast adenocarcinoma (1 ) and renal carcinoma (1).RESULTS Four of them had multiple bone metastasis. All 5 case had anorexia, nausea,polydipsia,polyuria,anxiety or apathy and ECG changes shown as shortness of S-T and large T wave. Serum calcium were: 3.75mmol/L, 3.5mmol/L, 3mmol/L,4.43mmol/L and 4.5mmol/L. With treatment by Bonefos (intravenous or orally),serum calcium returned to normal levels and symptoms were ameliorated.CONCLUSION For cases suspected of cancer-related hypercalcemia, timely examination can make the diagnosis and appropriated treatment can be given with good results.

关 键 词：肿瘤 高钙血症 治疗 

分 类 号：R730.6[医药卫生—肿瘤]