组织蛋白酶D在乳腺癌中的表达及其与转移的相关性研究  

EXPRESSION OF CATHEPSIN D IN INVASIVE BREAST CANCER AND ITS CORRELATION WITH METASTASIS

作　　者：李日乐[1] 张育东 田明铭[1] 樊剑芳[1] 姜文霞[1] 汤如勇[1] 

机构地区：[1]上海铁道大学附属甘泉医院病理科

出　　处：《中国癌症杂志》1996年第3期192-194,共3页China Oncology

摘　　要：目的探讨组织蛋白酶Ｄ（ｃａｔｈｅｐｓｉｎＤ，ＣＤ）在乳腺癌中的表达及其与转移的关系。方法应用ＣＤ多克隆抗体对７２例乳腺浸润性导管癌（以下简称乳腺癌）进行了免疫组织化学研究。结果乳腺癌ＣＤ阳性细胞的分布极不一致，可能与乳腺癌的生长方式及异质性有关；腋下淋巴结阳性病例组中ＣＤ高表达者明显多于腋下淋巴结阴性（ｎｏｄｅ－ｎｅｇａｔｉｖｅｂｒｅａｓｔｃａｎｃｅｒ，ＮＮＢＣ）病例组（Ｐ＜０．００５）；乳腺癌术后复发及远处转移者均为高水平ＣＤ表达；３４例ＮＮＢＣ的ＣＤ表达差异颇大，其中有１０例ＣＤ完全阴性，８例低表达，１６例高表达。结论ＣＤ表达与乳腺癌转移密切相关，ＣＤ高表达者术后复发、远处转移的可能性大。To study the expression of cathepsin D (CD) and its correlation with metastasis in invasive breast cancer.METHODS 72 cases of invasive breast carcinoma specimens were stained immunohistochemically forcathepsin. The results were analysed by chi-square test.RESULTS The distribution of CD-positive tumor cells was heterogeneous ICD expression was significantly associated with lymph node status:high-level CD expression was frequently found in node-positivebreast cancer cases (P<0. 005). All cases with postoperative recurrence or distant metastasis expressedhigh levels of CD. Among the 34 cases of node-negative breast cancer (NNBC), CD expression variedmarkedly. 10 of them had completely negative expression, while & had low expression, and 16 had high expression.CONCLUSIONS Expression of CD correlates well with metastasis in breast cancer and those caseswith high-level CD expression might be at high risk for recurrence and distant metastases and might benefitfrom aggressive adjuvant therapy.

关 键 词：肿瘤转移 组织蛋白酶 乳腺肿瘤 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]