枢丹预防化疗药物致胃肠道反应的效果观察  

THE EFFICACY OF ZUDAN IN CHEMOTHERAPY INDUCED EMESIS

作　　者：何桂芬[1] 唐惟瑜[1] 许立功[1] 洪小南[1] 

机构地区：[1]上海医科大学附属肿瘤医院

出　　处：《中国癌症杂志》1996年第4期256-257,共2页China Oncology

摘　　要：目的观察枢丹对化疗患者的止吐效果。方法５０例恶性肿瘤患者在化疗同时并用枢丹。患者分为两组：顺铂（ＤＤＰ）组３０例，初治者１０例，复治者２０例；非ＤＤＰ组２０例；全为复治者（即第１次用该化疗方案有呕吐者，在第２次用同样化疗方案时加用枢丹）。结果枢丹对化疗患者的止吐效果为６８．０％（３４／５０），其中在ＤＤＰ组为主的联合化疗方案中有效率为７０．０％（２１／３０），在非ＤＤＰ组为６５．０％（１３／２０）。无严重不良反应。结论枢丹对化疗患者有好的止呕吐作用，且副作用轻。To observe the efficacy of Zudan,a selective 5-HT3 receptor antagonist,as an anti-emetic agent in chemotherapy induced emesls.METHODS 50 patients with malignant diseases receiving combination chemotherapy were given Zudan from March 1995 to January 1996.RESULTS Emesis was observed in 68% (34/50) of the patients. The efficacy of Zudan in preventing the emesis induced by the DDP containing regimens was 70% (21/30), whereas in non-DDP regimen cases,it was 65% (13/20).CONCLUSIONS Zudan has been shown to be an effective anti-emetic with mild toxicity.

关 键 词：枢丹 止吐药 药物疗法 恶心 

分 类 号：R730.53[医药卫生—肿瘤]