酒精性肝纤维化的病理研究  

Pathological Study of Alcoholic Hepatic Fibrosis

作　　者：赵静波[1] 王泰龄[1] 张道明[1] 刘霞[1] 张晶[1] 

机构地区：[1]北京中日友好医院病理科,100029

出　　处：《实用肝脏病杂志》1996年第2期67-69,共3页Journal of Practical Hepatology

摘　　要：本文观察了66例酒精性肝病(ALD)的肝纤维化特点。酒精性肝纤维化(AHF)主要有三种形成方式:①窦周纤维化,最具特征;②静脉周围纤维化;③汇管区及汇管区周围纤维化,后者包括汇管区胶原增多,扩大,汇管区周围星芒状纤维化及界板侵蚀。重度AHF时以Ⅰ型胶原沉积为主。AHF的形成与Ito细胞增殖密切相关。图像定量分析表明,酒精性肝病肝纤维化程度重于慢性病毒性肝炎者。The chracteristies of fibrosis in 66 liver biopsies of aloholic liver disease (ALD) were analyzed by routine pathological staining and immunohistochemistry. The results showed that aloholie hepatic fibrosis had three morphological types:1.Perisinosoidal fibro-sis (PSF) ;2.Terminal venous fibrosis (TVF) and 3.Portal and Periportal fibrosis. Proliferative collagen was mainly type I col-lagen in serious fibrosis.Close relationship between fibrosis and proliferation of Ito cells was demonstrated by the α-SMA staining. Image-analysis showed that the percentage of fibrous tissues was higher in ALD than that in chronic viral hepatitis at same stage of fibrosis.

关 键 词：酒精性肝纤维化 病理研究 免疫组化 图像分析 

分 类 号：R575.2[医药卫生—消化系统]