harmacokinetics of Tetramethylpyrazine Phosphate inHealthy and Blood Stasis Dogs in vivo  

作　　者：蒋永培 文爱东 黄熙 臧益民 张雷华 

出　　处：《Chinese Journal of Integrative Medicine》1996年第2期132-134,共3页中国结合医学杂志（英文版）

摘　　要：To test the hypotliesis of Syndrome and Treatment Pharmacokinetics (S-TPK ) , tlie authorsbeve stodied tlie pharmacokinetics of tetramethyrazine phosphate (TMPP) in healthy and blood stasis dogs byhigh performance liquid chromatography. After a single intravenous injection ot TMPP & mg` kg i to healthyand blood stasis dogs, compartment model of TMPP serum concontration was fitted and then pharmacokineticparameters were calculated with a Microcomputer Pharmacokinetic Program on a Compaq 80386 computer.lmportant parameters were as follows: in the healthy dogs, T1/2 = 30. 27 ±6. 85 min. Kel = 0. 11 ± 0. 04min-1 , AUC = 445. 26 ± 51 . 26 mg/L.min , in the blood stasis dogs, min, Kel = 0. 06±0 . 01 min -1 , AUC = 1381 . 85 ± 464 . 68 mg/L. min. Through this experiment it was found that there was sig-nificant differefico in the pharmacokinetic parameters between healthy and blood stasis dogs. The results ob-tained are consistent with S-TPK hypotbesis.

关 键 词：traditional Chinese medicine TETRAMETHYLPYRAZINE blood stasis PHARMACOKINETICS highperformance liquid chromatography 

分 类 号：R96[医药卫生—药理学]