血清PⅢP检测对肝硬化患者的临床意义  

The Clinical Significance of the Serum Procollagen Peptide in Hepatic Cirrhosis

作　　者：张琪[1] 江月萍[1] 郭英华[1] 王筱如 

机构地区：[1]青岛医学院附属医院,266001

出　　处：《青岛医药卫生》1996年第4期3-5,共3页Qingdao Medical Journal

摘　　要：测定了35例肝硬化失代偿期患者血清PⅢP水平,并与40例正常人对照。结果发现,肝硬化组PⅢP含量高于正常组(P<0.001),Child分级C组PⅢP含量高于A组(P<0.05),肝硬化组PⅢP含量与白蛋白含量呈负相关。说明随肝硬化病情加重PⅢP含量增高,血清PⅢP含量检测有助于肝纤维化病情的观察及反映肝功能的变化。与肝活检相比较,血清PⅢP检测的无创伤性,可重复性使其在估计肝纤维化程度、抗纤维化药物治疗的选择等方面具有更大的临床实用价值。Serum procollagen peptide (P III P)concentrations was measured in 40 healthy adults (control group)and 35 patients with cirrhosis. There were significant differences be tween normal controls and patients with hepatic cirrhosis (P<0. 001). The results suggested that some significant changes according to their relation with the function of liver. The serum P III P level could reliably reflect the degree of liver fibrosis,the prognostic value of liver cirrhosis and may provide a convenient way for estimating the effect of antifibrotic drugs on liver fibrosis.

关 键 词：血清PⅢP 肝硬化 肝纤维化 

分 类 号：R575.2[医药卫生—消化系统]