Immunoregulation　of　Lupus－like　NZB／W　F_1　Mice　by　Antimurine　IL－1α，IL－6　Antibodies  

作　　者：刘文励 孙汉英 邵静芳 徐慧珍 沈关心 

出　　处：《Journal of Huazhong University of Science and Technology(Medical Sciences)》1996年第4期209-211,共3页华中科技大学学报（医学英德文版）

摘　　要：Anti-murine IL-1α, IL-6 antibodies were intra-peritoneally injected to the lupus-like NZB/W F1 mice of 4 months with the dosage of 10μg per day for three days and then per month for three months. The mice were killed at the age of 11 months. The results showed that the treatment of the dosage could not absolutely prevent lupus nephritis; it could alleviate proteinuria, obviously reduce the levels of serum IL-lα and inhibit the secretion of IL-1α by celiac macrophage.As to the level of IL-6 and TNF-α no significant change was observed.Anti-murine IL-1α, IL-6 antibodies were intra-peritoneally injected to the lupus-like NZB/W F1 mice of 4 months with the dosage of 10μg per day for three days and then per month for three months. The mice were killed at the age of 11 months. The results showed that the treatment of the dosage could not absolutely prevent lupus nephritis; it could alleviate proteinuria, obviously reduce the levels of serum IL-lα and inhibit the secretion of IL-1α by celiac macrophage.As to the level of IL-6 and TNF-α no significant change was observed.

关 键 词：NZB/W F_1 mouse anti-IL-1α antibody anti-IL-6 antibody IMMUNOREGULATION 

分 类 号：R392[医药卫生—免疫学]