Effects　of　Phentolamine　on　Hemorrheology　and　Hemodynamics　in　Dogs　with　Acute　Liver　Damage  

作　　者：但自力 张文英 李绍白 

出　　处：《Journal of Huazhong University of Science and Technology(Medical Sciences)》1996年第3期164-167,共4页华中科技大学学报（医学英德文版）

摘　　要：The effects of phentolamine on hemorrheology and hemodynamics were studied in dogs with acute liver damage induced by acetaminophen. After 1 h of phentolamine application , the viscosity of plasma and whole blood was significantly diminished. The hematocrit readings followed the same pattern as the alterations in viscosity. The portal venous resistance and the value of K were remarkably decreased and the portal venous blood flow was obviously increased. It can be assumed , therefore , that the decrease in viscosity induced by phentolamine results from internal hemodilution and phentolamine may improve hepatic blood circulation through the decrease of portal venous resistance caused by the reduction of blood viscosity and the dilation of portal vascular beds.The effects of phentolamine on hemorrheology and hemodynamics were studied in dogs with acute liver damage induced by acetaminophen. After 1 h of phentolamine application , the viscosity of plasma and whole blood was significantly diminished. The hematocrit readings followed the same pattern as the alterations in viscosity. The portal venous resistance and the value of K were remarkably decreased and the portal venous blood flow was obviously increased. It can be assumed , therefore , that the decrease in viscosity induced by phentolamine results from internal hemodilution and phentolamine may improve hepatic blood circulation through the decrease of portal venous resistance caused by the reduction of blood viscosity and the dilation of portal vascular beds.

关 键 词：PHENTOLAMINE blood viscosity hemdynamics acute liver damage liver circulation HEMODILUTION 

分 类 号：R965[医药卫生—药理学]