THE　RELATIONSHIP　BETWEEN　THE　CONCENTRATION　OF　METHIMAZOLE　IN　PLASMA　AND　INTRATHYROID　AND　ITS　CURATIVE　EFFECT  

作　　者：姜薇 高慧 

出　　处：《Journal of Pharmaceutical Analysis》1995年第1期63-66,共4页药物分析学报（英文版）

摘　　要：In order to investigate the relationship between concentration of methimazole(MMTand clinical curative efficacy,the concentration of MMI in Plasma and thyroid tissue was measuredin 26 patients with Graves' disease by HPLC,meanwhile their T-lymphocyte subsets,thyroid autoimmune antibodies and serum immunoglobulin were also measured.The results showed: ① The plasmaand intrathyroid concentrations of MMI of recovery group were much higher than those of unrecovery group(P<0.001).② The hardness of thyroid had a significant effect on the concentration ofMMI in thyroid.③Plasma concentration of MMI in the patients with no or 1￣2-degree enlargement of thyroid was much higher than that in the patients with 3-degree enlargement of thyroid(P<0.001). In addition, the plasma concentration of MMI in the subjects with soft thyroid was mudhigher than that in those with hard thyroid(P<0.001).Our study demonstrated that MMI playeda role in the immune supression of thyroid autoimmune antibodies and the immune regulation of Tand B-lymphocytes.Effective MMI concentration in the plasma and intrathyroid is the key of thesuccessful clinical treatment and correlates with the size and hardness of thyroid.In order to investigate the relationship between concentration of methimazole(MMTand clinical curative efficacy,the concentration of MMI in Plasma and thyroid tissue was measuredin 26 patients with Graves' disease by HPLC,meanwhile their T-lymphocyte subsets,thyroid autoimmune antibodies and serum immunoglobulin were also measured.The results showed: ① The plasmaand intrathyroid concentrations of MMI of recovery group were much higher than those of unrecovery group(P<0.001).② The hardness of thyroid had a significant effect on the concentration ofMMI in thyroid.③Plasma concentration of MMI in the patients with no or 1￣2-degree enlargement of thyroid was much higher than that in the patients with 3-degree enlargement of thyroid(P<0.001). In addition, the plasma concentration of MMI in the subjects with soft thyroid was mudhigher than that in those with hard thyroid(P<0.001).Our study demonstrated that MMI playeda role in the immune supression of thyroid autoimmune antibodies and the immune regulation of Tand B-lymphocytes.Effective MMI concentration in the plasma and intrathyroid is the key of thesuccessful clinical treatment and correlates with the size and hardness of thyroid.

关 键 词：Graves disease piasma THYROID METHIMAZOLE clinical curative effect 

分 类 号：R36[医药卫生—病理学]