THE　EXPERIMENTAL　STUDY　OF　SEALING　THE　HEPATIC　TRAUMATIC　CHANNEL　WITH　THROMBIN　ON　CANINES  

作　　者：吕毅 孟令忠 潘承恩 于良 

出　　处：《Journal of Pharmaceutical Analysis》1995年第2期115-119,共5页药物分析学报（英文版）

摘　　要：In order to solve the problem of intraperitoneal haemorrhage and bile leakage caused by the iatrogenic trauma, sixty-four sequence of puncture were performed on twenty canine livers and thirty-two sequences selected by chance were perfused with thrombin solution. The results revealed that the bleeding time was shortened and amounts lessened significantly after application of thrombin compared with counterparts of control (P< 0. 001,t test).There was no significant difference between the levels of plasma fibringgeu prc-and Post-thrombin's using (P > 0.4,t test).The thrombin clotting time of patients with obstructive jaundice was similar to that of the group of control(P> 0. 05, t test).We conclude that thrombin is characterized by the ability of rapid,effective and safe haemostasis to the traumatic channel made by the liver puncture,and it's adaptive to most of the patients with hepatobiliary disease,and worth using and developing in clinical practice.In order to solve the problem of intraperitoneal haemorrhage and bile leakage caused by the iatrogenic trauma, sixty-four sequence of puncture were performed on twenty canine livers and thirty-two sequences selected by chance were perfused with thrombin solution. The results revealed that the bleeding time was shortened and amounts lessened significantly after application of thrombin compared with counterparts of control (P< 0. 001,t test).There was no significant difference between the levels of plasma fibringgeu prc-and Post-thrombin's using (P > 0.4,t test).The thrombin clotting time of patients with obstructive jaundice was similar to that of the group of control(P> 0. 05, t test).We conclude that thrombin is characterized by the ability of rapid,effective and safe haemostasis to the traumatic channel made by the liver puncture,and it's adaptive to most of the patients with hepatobiliary disease,and worth using and developing in clinical practice.

关 键 词：trau0matic channel of liver THROMBIN HAEMOSTASIS 

分 类 号：R657.3[医药卫生—外科学]