云南高校图书馆联盟文献共享服务平台- THROMBIN

THROMBIN: 作品数：111被引量：321H指数：9; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：王琪黄山杨天波吴飞翔赵荫农更多>>; 相关机构：广西医科大学附属肿瘤医院广西医科大学浙江大学医学院附属第二医院郑州大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金海南省自然科学基金更多>>

Injectable Nanorobot-Hydrogel Superstructure for Hemostasis and Anticancer Therapy of Spinal Metastasis: 《Nano-Micro Letters》2024年第12期59-80,共22页Qing Chen Miao Yan Annan Hu Bing Liang Hongwei Lu Lei Zhou Yiqun Ma Chao Jia Dihan Su Biao Kong Wei Hong Libo Jiang Jian Dong; supported by the National Natural Science Foundation of China(No.52103171,82172738,82272457,22305044);China Postdoctoral Science Foundation(2023M730638);“Technology Innovation Action Plan”of Science and Technology Commission of Shanghai Municipality(21S11902700);Natural Science Foundation of Shanghai(21ZR1412300),Shanghai Science and Technology program(23Y31900202,23010502600);Shanghai“Rising Stars of Medical Talent”Youth Development Program(Youth Medical Talents-Specialist Program,[2020]087);Medical Engineering fund of Fudan University(yg2023-27).; Surgery remains the standard treatment for spinal metastasis.However,uncontrolled intraoperative bleeding poses a significant challenge for adequate surgical resection and compromises surgical outcomes.In this study,w...; 关键词：Silk fibroin Nanofibril hydrogels Nanorobots THROMBIN Spinal metastasis

The Exploration on the Anti-inhibitor Ability of the DNATyper^(TM)21 Kit: 《刑事技术》2024年第6期619-625,共7页CHEN Liwei YANG Xingyi YU Zhengliang; 法医遗传学公安部重点实验室开放课题(2021FGKFKT06);中央级公益性科研院所基本科研业务费专项资金项目(2021JB005)。; The DNATyper^(TM)21 kit has good species specificity,typing accuracy,and locus amplification balance,which can be used for forensic genetic analysis such as individual identification and paternity testing.To improve t...; 关键词：autosomal STR DNATyper^(TM)21 kit PCR inhibitors bovine serum albumin bovine thrombin

When Glanzmann thrombasthenia encounters antithrombin defi ciency: how do we balance the risk and benefi t of antithrombotic therapy?: 《World Journal of Emergency Medicine》2024年第1期67-69,共3页Yu Wang Zhihao Liu Haoyu Weng Jianping Li; Glanzmann’s thrombasthenia(GT)is an inherited autosomal recessive bleeding disorder,resulting from mutations in the ITGA2B and ITGB3 genes,that lead to a defect in the platelet membrane integrinαIIbβ3.[1]As integri...; 关键词：THROMBIN throm BLEEDING

Argatroban promotes recovery of spinal cord injury by inhibiting the PAR1/JAK2/STAT3 signaling pathway被引量：3: 《Neural Regeneration Research》2024年第2期434-439,共6页Chenxi Zhao Tiangang Zhou Ming Li Jie Liu Xiaoqing Zhao Yilin Pang Xinjie Liu Jiawei Zhang Lei Ma Wenxiang Li Xue Yao Shiqing Feng; supported by the Key Project of the National Natural Science Foundation of China,No.81930070(to SF);the National Natural Science Foundation of China,No.81972074(to XY);the Key Program of Natural Science Foundation of Tianjin,No.19JCZDJC34900(to XY)。; Argatroban is a synthetic thrombin inhibitor approved by U.S.Food and Drug Administration for the treatment of thrombosis.However,whether it plays a role in the repair of spinal cord injury is unknown.In this study,we...; 关键词：ARGATROBAN ASTROGLIOSIS JAK/STAT signaling pathway protease-activated receptor-1 spinal cord injury THROMBIN vimentin

Transplantation of fibrin-thrombin encapsulated human induced neural stem cells promotes functional recovery of spinal cord injury rats through modulation of the microenvironment被引量：2: 《Neural Regeneration Research》2024年第2期440-446,共7页Sumei Liu Baoguo Liu Qian Li Tianqi Zheng Bochao Liu Mo Li Zhiguo Chen; supported by the Stem Cell and Translation National Key Project,No.2016YFA0101403(to ZC);the National Natural Science Foundation of China,Nos.82171250 and 81973351(to ZC);the Natural Science Foundation of Beijing,No.5142005(to ZC);Beijing Talents Foundation,No.2017000021223TD03(to ZC);Support Project of High-level Teachers in Beijing Municipal Universities in the Period of 13th Five-year Plan,No.CIT&TCD20180333(to ZC);Beijing Municipal Health Commission Fund,No.PXM2020_026283_000005(to ZC);Beijing One Hundred,Thousand,and Ten Thousand Talents Fund,No.2018A03(to ZC);the Royal Society-Newton Advanced Fellowship,No.NA150482(to ZC);the National Natural Science Foundation of China for Young Scientists,No.31900740(to SL)。; Recent studies have mostly focused on engraftment of cells at the lesioned spinal cord,with the expectation that differentiated neurons facilitate recovery.Only a few studies have attempted to use transplanted cells a...; 关键词：biomaterial FIBRINOGEN functional recovery induced neural stem cell transplantation MICROENVIRONMENT MICROGLIA spinal cord injury THROMBIN

Thrombin increases the expression of cholesterol 25-hydroxylase in rat astrocytes after spinal cord injury被引量：6: 《Neural Regeneration Research》2023年第6期1339-1346,共8页Chen Chen Huiyuan Ji Nan Jiang Yingjie Wang Yue Zhou Zhenjie Zhu Yuming Hu Yongjun Wang Aihong Li Aisong Guo; supported by the National Natural Science Foundation of China;No.81971826 (to AG);the China Postdoctoral Science Foundation;No.2020M681 689 (to YH);the Scientific Research Project of The Health Commission of Jiangsu Province;No.ZDB2020003 (to AG);the Basic Scientific Research Projects of Nantong;No.JC2020041 (to YH); Astrocytes are important cellular centers of cholesterol synthesis and metabolism that help maintain normal physiological function at the organism level.Spinal cord injury results in aberrant cholesterol metabolism by...; 关键词：25-hydroxycholesterol ASTROCYTE CHEMOTAXIS cholesterol metabolism cholesterol-25-hydroxylase lipid homeostasis macrophage PAR1 spinal cord injury THROMBIN

An excimer ‘ON–OFF’ switch based on telomeric G-quadruplex and rGO for trace thrombin detection: 《Chinese Chemical Letters》2022年第9期4243-4247,共5页Long Zhao Farid Ahmed Hai Xiong; supported by the Science and Technology Innovation Commission of Shenzhen,China(Nos.KQJSCX20180328095517269 and JCYJ20210324095607021)。; In the recent decade,GO has emerged as an amazing 2D nanomaterial for developing DNA-based biosensors due to its fluorescence quenching properties,whereas similar research based on rGO was reported rarely.Herein,a nov...; 关键词：G-quadruplexr GOMulti-pyrene excimer BIOSENSOR Thrombin detection

Progress in DNA Aptamers as Recognition Components for Protein Functional Regulation: 《Chemical Research in Chinese Universities》2022年第4期894-901,共8页HU Lingling LIU Ke REN Guolan LIANG Jiangong WU Yuan; supported by the National Natural Science Foundation of China(No.21904046).; Proteins play a central role in all domains of life,and precise regulation of their activity is essential for understanding the related biological processes and therapeutic functions.Nucleic acid aptamers,the molecula...; 关键词：APTAMER Protein activity regulation Systematic evolution of ligands by exponential enrichment(SELEX)Membrane receptor THROMBIN

MCAO模型大鼠不同缺血时相、不同脑区Thrombin与LC3Ⅱ/Ⅰ表达的相关性研究被引量：1: 《湖南中医药大学学报》2022年第6期899-905,共7页马若梦李定祥彭珣李钰佳阳晶晶邓奕辉; 国家自然科学基金项目(81874416)。; 目的研究缺血性中风瘀毒互结模型(简称“IS-YD”)大鼠在不同缺血时相、不同脑区凝血酶(Thrombin)与微管相关蛋白1轻链3(light chain 3,LC3)的动态性变化及二者的相关性。方法将128只SD雄性大鼠随机分为假手术组、IS-YD(2 h、4 h、8 h、1...; 关键词：凝血酶自噬缺血性中风瘀毒互结化瘀解毒法微管相关蛋白1轻链3 2 3 5-三苯基氯化四氮唑

Photo-Initiated Coagulation Activation and Fibrinolysis Inhibition for Synergetic Tumor Vascular Infarction via a Gold Nanorods-Based Nanosystem: 《CCS Chemistry》2022年第5期1770-1787,共18页Sheng Hong Qian-Xiao Huang Zhenlin Zhong Lei Rong Xian-Zheng Zhang; supported by the National Natural Science Foundation of China(grant nos.51988102,51833007,51690152,51533006,and 21721005);the National Key Research and Development Program of China(grant no.2019YFA0905603).; Tumor vascular infarction has been regarded as a promising therapy in tumor treatment.However,due to the limited activity of designed coagulation agents,resulting from the challenges of inducing sustained and complete...; 关键词：vascular infarction COAGULATION FIBRINOLYSIS gold nanorod THROMBIN tranexamic acid

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