ASTROGLIOSIS

作品数：26被引量：145H指数：6
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相关领域：医药卫生生物学更多>>
相关作者：朱燕玲高亮苏志达曹莉何成更多>>
相关机构：第二军医大学更多>>
相关期刊：《Frontiers in Biology》《Regenerative Biomaterials》《Acta Pharmacologica Sinica》《Science Bulletin》更多>>
相关基金：国家自然科学基金北京市自然科学基金国家重点基础研究发展计划天津市自然科学基金更多>>
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Astrocytes, reactive astrogliosis, and glial scar formation in traumatic brain injury被引量：2
《Neural Regeneration Research》2025年第4期973-989,共17页María Belén Cieri Alberto Javier Ramos 
supported by grants PICT 2019-0851;2017-2203,UBACYT and PIP CONICET(to AJR).
Traumatic brain injury is a global health crisis,causing significant death and disability worldwide.Neuroinflammation that follows traumatic brain injury has serious consequences for neuronal survival and cognitive im...
关键词：ASTROCYTE glial scar innate immunity NEUROINFLAMMATION stab injury Toll-like receptors 
Novel mouse model of Alzheimer's disease exhibits pathology through synergistic interactions among amyloid-β,tau,and reactive astrogliosis
《Zoological Research》2025年第1期41-53,共13页Young-Eun Han Sunhwa Lim Seung Eun Lee Min-Ho Nam Soo-Jin Oh 
supported by the National Research Foundation of Korea (NRF)funded by the Ministry of Science,ICT&Future Planning (2022R1A2C2006229,2022R1A6A3A01086868);Korea Dementia Research Project through the Korea Dementia Research Center (KDRC)funded by the Ministry of Health&Welfare and Ministry of Science and ICT,Republic of Korea (RS-2024-00345328);KIST Institutional Grant (2E32851)。
Alzheimer'sdisease(AD)isaprogressive neurodegenerative disorder characterized by cognitive impairment and distinct neuropathological features,including amyloid-βplaques,neurofibrillary tangles,and reactive astroglios...
关键词：Alzheimer's disease mouse model Neurofibrillary tangles Amyloid-βplaques Reactive astrogliosis Alzheimer’s disease pathology 
From Physiology to Pathology of Astrocytes:Highlighting Their Potential as Therapeutic Targets for CNS Injury
《Neuroscience Bulletin》2025年第1期131-154,共24页Yimin Yuan Hong Liu Ziwei Dai Cheng He Shangyao Qin Zhida Su 
supported by the National Natural Science Foundation of China(82171386,81971161,and 82201536);the Shanghai Science and Technology Development Foundation(22YF1458600);the Scientifc Foundation from Naval Medical University(2021QN08);the STI2030-Major Projects from Ministry of Science and Technology of China(2022ZD0204700).
In the mammalian central nervous system(CNS),astrocytes are the ubiquitous glial cells that have complex morphological and molecular characteristics.These fascinating cells play essential neurosupportive and homeostat...
关键词：ASTROCYTES Reactive astrocyte ASTROGLIOSIS CNS injury REPAIR 
Star power: harnessing the reactive astrocyte response to promote remyelination in multiple sclerosis
《Neural Regeneration Research》2024年第3期578-582,共5页Markley Silva Oliveira Junior Laura Reiche Emerson Daniele Ines Kortebi Maryam Faiz Patrick Küry 
supported by the Heart and Stroke Foundation and Ontario Institute of Regenerative Medicine (New Ideas Grant);Canada First Research Excellence Fund(Medicine by Design);the National Sciences and Engineering Research Council;the Jurgen Manchot Foundation;the Christiane and Claudia Hempel Foundation for Clinical Stem Cell Research and the James and Elisabeth Cloppenburg,Peek and Cloppenburg Düsseldorf Stiftung (to PK)
Astrocytes are indispensable for central nervous system development and homeostasis.In response to injury and disease,astrocytes are integral to the immunological-and the,albeit limited,repair response.In this review,...
关键词：ASTROCYTES DEMYELINATION drug-based therapies myelin repair oligodendrocyte precursor cells reactive astrogliosis 
Argatroban promotes recovery of spinal cord injury by inhibiting the PAR1/JAK2/STAT3 signaling pathway被引量：3
《Neural Regeneration Research》2024年第2期434-439,共6页Chenxi Zhao Tiangang Zhou Ming Li Jie Liu Xiaoqing Zhao Yilin Pang Xinjie Liu Jiawei Zhang Lei Ma Wenxiang Li Xue Yao Shiqing Feng 
supported by the Key Project of the National Natural Science Foundation of China,No.81930070(to SF);the National Natural Science Foundation of China,No.81972074(to XY);the Key Program of Natural Science Foundation of Tianjin,No.19JCZDJC34900(to XY)。
Argatroban is a synthetic thrombin inhibitor approved by U.S.Food and Drug Administration for the treatment of thrombosis.However,whether it plays a role in the repair of spinal cord injury is unknown.In this study,we...
关键词：ARGATROBAN ASTROGLIOSIS JAK/STAT signaling pathway protease-activated receptor-1 spinal cord injury THROMBIN vimentin 
Propofol Protects Regulatory T Cells, Suppresses Neurotoxic Astrogliosis, and Potentiates Neurological Recovery After Ischemic Stroke被引量：3
《Neuroscience Bulletin》2021年第5期725-728,共4页Yuzhu Wang Dan Tian Yushang Zhao Mengyao Qu Yuhualei Pan Changwei Wei Yanbing Zhu Anshi Wu 
supported by the National Natural Science Foundation of China (81771139);Beijing Natural Science Foundation (7194270)。
Dear Editor,Emergency intravascular thrombectomy is the best treatment for acute ischemic stroke [1]. However, it is controversial whether the use of general anesthesia during emergency intravascular thrombectomy affe...
关键词：ANESTHESIA acute INTRAVASCULAR 
Role of Elevated Thrombospondin-1 in Kainic Acid-Induced Status Epilepticus被引量：2
《Neuroscience Bulletin》2020年第3期263-276,共14页Yurong Zhang Mengdi Zhang Wei Zhu Xiaohong Pan Qiaoyun Wang Xue Gao Chaoyun Wang Xiuli Zhang Yuxia Liu Shucui Li Hongliu Sun 
the National Natural Science Foundation of China(81573412);the Key Research and Development Plan(2018GSF121004);the Natural Science Foundation of Shandong Province,China(ZR2014JL055).
Previous studies have suggested that thrombospondin-1(TSP-1) regulates the transforming growth factor beta 1(TGF-b1)/phosphorylated Smad2/3(p Smad2/3) pathway. Moreover, TSP-1 is closely associated with epilepsy. Howe...
关键词：ASTROGLIOSIS STATUS epilepticus PONATINIB Thrombospondin-1 
Roles of miRNAs in spinal cord injury and potential therapeutic interventions被引量：1
《Neuroimmunology and Neuroinflammation》2019年第10期1-11,共11页Badria Almurshidi Wayne Carver Geoff Scott Swapan K.Ray 
The work was supported in part by an investigator-initiated research grant(SCIRF-2015-1-01)from South Carolina Spinal Cord Injury Research Fund(Columbia,SC,USA);an award from the Soy Health Research Program(SHRP,United Soybean Board,Chesterfield,MO,USA);and earlier R01 grants(CA-091460 and NS-057811)from the National Institutes of Health(Bethesda,MD,USA).
Spinal cord injury(SCI)affects approximately 200,000 individuals per year worldwide.There are more than 27 million people worldwide living with long-term disability due to SCI.Historically,it was thought that the cent...
关键词：Spinal cord injury MIRNAS ASTROGLIOSIS neuropathic pain INFLAMMATION APOPTOSIS functional recovery 
CID 1067700, a late endosome GTPase Rab7 receptor antagonist, attenuates brain atrophy, improves neurologic deficits and inhibits reactive astrogliosis in rat ischemic stroke被引量：3
《Acta Pharmacologica Sinica》2019年第6期724-736,共13页Yuan Qin Yang He Yong-ming Zhu Min Li Yong Ni Jin Liu Hui-ling Zhang 
National Natural Science Foundation of China (No 30973510, 81171104, 81473211);Jiangsu Key Laboratory of Neuropsychiatric Diseases (No BM2013003);Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, and a project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).
Increasing evidence suggests that Ras-related in brain 7 (Rab7), an endosome-localized small GTPase contributes to cerebral ischemic brain injury. In the present study, we investigated the role of Rab7 in ischemic str...
关键词：ischemic stroke ASTROCYTES Rab7 CID1067700 GLIAL scar LYSOSOME 
Fibroadhesive scarring of grafted collagen scaffolds interferes with implant–host neural tissue integration and bridging in experimental spinal cord injury被引量：5
《Regenerative Biomaterials》2019年第2期75-87,共13页Haktan Altinova Sebastian Hammes Moniek Palm Jose Gerardo-Nava Pascal Achenbach Ronald Deumens Emmanuel Hermans Tobias Fuhrmann Arne Boecker Sabien Geraldine Antonia van Neerven Ahmet Bozkurt Joachim Weis Gary Anthony Brook 
supported by the START-Program of the Faculty of Medicine,RWTH Aachen.
Severe traumatic spinal cord injury(SCI)results in a devastating and permanent loss of function,and is currently an incurable condition.It is generally accepted that future intervention strategies will require combina...
关键词：spinal cord injury CNS-scarring type-I collagen SCAFFOLD ASTROGLIOSIS FIBROSIS encapsulation 
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