From Physiology to Pathology of Astrocytes:Highlighting Their Potential as Therapeutic Targets for CNS Injury  

作　　者：Yimin Yuan Hong Liu Ziwei Dai Cheng He Shangyao Qin Zhida Su 

机构地区：[1]Institute of Neuroscience,Key Laboratory of Molecular Neurobiology of Ministry of Education and the Collaborative Innovation Center for Brain Science,Naval Medical University,Shanghai 200433,China [2]Department of Pain Medicine,School of Anesthesiology,Naval Medical University,Shanghai 200433,China

出　　处：《Neuroscience Bulletin》2025年第1期131-154,共24页神经科学通报(英文版)

基　　金：supported by the National Natural Science Foundation of China(82171386,81971161,and 82201536);the Shanghai Science and Technology Development Foundation(22YF1458600);the Scientifc Foundation from Naval Medical University(2021QN08);the STI2030-Major Projects from Ministry of Science and Technology of China(2022ZD0204700).

摘　　要：In the mammalian central nervous system(CNS),astrocytes are the ubiquitous glial cells that have complex morphological and molecular characteristics.These fascinating cells play essential neurosupportive and homeostatic roles in the healthy CNS and undergo morphological,molecular,and functional changes to adopt so-called‘reactive’states in response to CNS injury or disease.In recent years,interest in astrocyte research has increased dramatically and some new biological features and roles of astrocytes in physiological and pathological conditions have been discovered thanks to technological advances.Here,we will review and discuss the wellestablished and emerging astroglial biology and functions,with emphasis on their potential as therapeutic targets for CNS injury,including traumatic and ischemic injury.This review article will highlight the importance of astrocytes in the neuropathological process and repair of CNS injury.

关 键 词：ASTROCYTES Reactive astrocyte ASTROGLIOSIS CNS injury REPAIR 

分 类 号：R74[医药卫生—神经病学与精神病学]