ARGATROBAN

作品数：9被引量：29H指数：3
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相关领域：医药卫生更多>>
相关作者：章翔张志文蒋晓帆周中和曲方更多>>
相关机构：第四军医大学西京医院西安交通大学中国医科大学沈阳军区总医院更多>>
相关期刊：《外文科技期刊数据库（文摘版）医药卫生》《Neural Regeneration Research》《World Journal of Clinical Cases》《Journal of Pharmaceutical Analysis》更多>>
相关基金：天津市自然科学基金国家自然科学基金更多>>
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Argatroban promotes recovery of spinal cord injury by inhibiting the PAR1/JAK2/STAT3 signaling pathway被引量：3
《Neural Regeneration Research》2024年第2期434-439,共6页Chenxi Zhao Tiangang Zhou Ming Li Jie Liu Xiaoqing Zhao Yilin Pang Xinjie Liu Jiawei Zhang Lei Ma Wenxiang Li Xue Yao Shiqing Feng 
supported by the Key Project of the National Natural Science Foundation of China,No.81930070(to SF);the National Natural Science Foundation of China,No.81972074(to XY);the Key Program of Natural Science Foundation of Tianjin,No.19JCZDJC34900(to XY)。
Argatroban is a synthetic thrombin inhibitor approved by U.S.Food and Drug Administration for the treatment of thrombosis.However,whether it plays a role in the repair of spinal cord injury is unknown.In this study,we...
关键词：ARGATROBAN ASTROGLIOSIS JAK/STAT signaling pathway protease-activated receptor-1 spinal cord injury THROMBIN vimentin 
Effect of Butylphthalide Sodium Chloride Combined with Argatroban on Neurological Function in Patients with Ischemic Stroke
《外文科技期刊数据库(文摘版)医药卫生》2022年第9期106-109,共4页JIANGMin 
Objective: to explore the feasibility and effectiveness of butylphthalide sodium chloride combined with argatroban in the clinical treatment of patients with ischemic stroke. Methods: the study was conducted in a retr...
关键词：ischemic stroke butylphthalide sodium chloride ARGATROBAN neurological function daily living abi 
Efficacy and safety of argatroban in treatment of acute ischemic stroke:A meta-analysis被引量：8
《World Journal of Clinical Cases》2022年第2期585-593,共9页Bin Lv Fang-Fang Guo Jia-Cai Lin Feng Jing 
BACKGROUND Argatroban is a novel direct thrombin inhibitor that has been used for treatment of acute ischemic stroke(AIS).To our knowledge,no systematic analysis has assessed the efficacy and safety of argatroban for ...
关键词：ARGATROBAN Anticoagulation agents Acute ischemic stroke THROMBIN THROMBOLYSIS META-ANALYSIS 
Anticoagulation with direct thrombin inhibitors during extracorporeal membrane oxygenation被引量：13
《World Journal of Critical Care Medicine》2019年第6期87-98,共12页Barry Burstein Patrick M Wieruszewski Yan-Jun Zhao Nathan Smischney 
Use of extracorporeal membrane oxygenation to support patients with critical cardiorespiratory illness is increasing.Systemic anticoagulation is an essential element in the care of extracorporeal membrane oxygenation ...
关键词：EXTRACORPOREAL membrane OXYGENATION ANTICOAGULANTS Antithrombins BIVALIRUDIN ARGATROBAN Heparin 
Effect of argatroban on neurological function in patients with acute cerebral infarction and its mechanism被引量：1
《Journal of Hainan Medical University》2019年第3期56-60,共5页Mei-Qi Di Ling-Ling Hu Shu-Hua Gui Xiao-Jing Yin Chao-Sheng Li 
Objective: Analyze the effect of argatroban on neurological function in patients with acute cerebral infarction and explore its possible mechanisms. Methods: From August 2015 to August 2017, 140 patients with acute ce...
关键词：ARGATROBAN NEUROLOGICAL FUNCTION COAGULATION FUNCTION INFLAMMATORY FACTORS 
Novel degradation products of argatroban: Isolation, synthesis and extensive characterization using NMR and LC-PDA-MS/Q-TOF被引量：4
《Journal of Pharmaceutical Analysis》2018年第2期86-95,共10页Vinodh Guvvala Venkatesan Chidambaram Subramanian Jaya Shree Anireddy Mahesh Konda 
Forced degradation study of argatroban under conditions of hydrolysis(neutral, acidic and alkaline), oxidation,photolysis and thermal stress, as suggested in the ICH Q1 A(R2), was accomplished. The drug showed signifi...
关键词：ARGATROBAN FORCED degradation NMR LC-PDA LC-MS/Q-TOF-MSn 
A Review of an Unorthodox Argatroban Infusion Rate for Anticoagulation in a Patient Case
《Journal of Pharmacy and Pharmacology》2017年第4期189-193,共5页Erin Barnett Loesch Christopher Ryan Boldi 
Argatroban is an intravenous DTI （direct synthetic thrombin inhibitor） that is not routinely used for anticoagulation; thus, expertise surrounding its use is very limited. Therefore, this case reviews an unusually h...
关键词：ANTICOAGULATION ARGATROBAN direct thrombin inhibitor heparin resistance partial thromboplastin time. 
Argatroban抑制颈动脉球囊损伤后新生内膜的形成被引量：1
《中华神经外科疾病研究杂志》2002年第1期68-71,共4页张志文 章翔 蒋晓帆 薛菁晖 柳本■二 永田泉 菊池晴彦 
日本(竹世)川基金会资助项目
目的 观察特异性凝血酶抑制因子argatroban对颈动脉损伤后新生内膜形成的影响,探讨血管损伤后内膜增生、引起管腔狭窄的可能机制。方法32只SD大鼠于颈动脉球囊损伤后,经皮下埋置的渗透性微泵注射argatroban,分为高剂量组:40mg/周,n=9;...
关键词：凝血酶 颈动脉狭窄 血小板源生长因子 大鼠 
THE EFFECTS OF ARGATROBAN ON THROMBIN INDUCED CEREBROVASCULAR THROMBOEMBOLISM IN RABBITS
《Journal of Pharmaceutical Analysis》1999年第1期27-31,共5页刘俊田 
Sustained accumulation of 111 Indiumlabelled platelets is induced in the cerebral vasculature of rabbits by bolus intracarotid (i.c.) administration of thrombin. Bolus i.c. injection of the thrombin inhibitor Argatrob...
关键词：Argatrban RTPA THROMBIN THROMBOEMBOLISM 
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