Effect of argatroban on neurological function in patients with acute cerebral infarction and its mechanism  

作　　者：Mei-Qi Di Ling-Ling Hu Shu-Hua Gui Xiao-Jing Yin Chao-Sheng Li 

机构地区：[1]Department of Neurology,Wuxi Integrated Traditional Chinese and Western Medicine Hospital,Jiangsu Province,Wuxi,214041,China

出　　处：《Journal of Hainan Medical University》2019年第3期56-60,共5页海南医学院学报（英文版）

摘　　要：Objective: Analyze the effect of argatroban on neurological function in patients with acute cerebral infarction and explore its possible mechanisms. Methods: From August 2015 to August 2017, 140 patients with acute cerebral infarction who were admitted to the Department of Neurology in our hospital were divided into a control group and an observation group according to the lottery method, with 70 cases in each group. Patients in the conventional group received routine treatment. Patients in the treatment group received routine treatment plus argatroban. The changes of neurological function, coagulation function and inflammatory factors were observed in the two groups. Result: Before treatment, there were no significant differences in neurological function parameters, coagulation function indexes and inflammatory factors between the two groups. After treatment, the neurological function indexes NT-proBNP, NPY and S-100β levels, coagulation function index FIB level, inflammatory factor indicators MMP-9, Lp-PLA2 and Hcy, vascular endothelial function index ET levels decreased, coagulation Functional indicators PT, TT and APTT are both elevated, and NO and CGRP levels are elevated. The levels of NT-proBNP, NPY and S-100β, FIB level, MMP-9, Lp-PLA2 and Hcy, ET levels in the treatment group were lower than those in the conventional group, while the levels of PT, TT and APTT levels, and NO and CGRP levels were higher than the conventional group. Conclusion: Argatroban treatment can significantly improve neurological function in patients with acute cerebral infarction. The possible mechanism is to improve coagulation function, vascular endothelial function and relieve inflammatory stress response.

关 键 词：ARGATROBAN NEUROLOGICAL FUNCTION COAGULATION FUNCTION INFLAMMATORY FACTORS 

分 类 号：R5[医药卫生—内科学]