Efficacy and safety of argatroban in treatment of acute ischemic stroke:A meta-analysis  

作　　者：Bin Lv Fang-Fang Guo Jia-Cai Lin Feng Jing 

机构地区：[1]Department of Neurology,Chinese PLA General Hospital,Beijing 100853,China [2]Health Management Institute,The Second Medical Center&National Clinical Research Center for Geriatric Diseases,Chinese PLA General Hospital,Beijing 100853,China [3]Department of Neurology,Hainan Hospital of Chinese PLA General Hospital,Sanya 572022,Hainan Province,China

出　　处：《World Journal of Clinical Cases》2022年第2期585-593,共9页世界临床病例杂志

摘　　要：BACKGROUND Argatroban is a novel direct thrombin inhibitor that has been used for treatment of acute ischemic stroke(AIS).To our knowledge,no systematic analysis has assessed the efficacy and safety of argatroban for treatment of AIS.AIM To evaluate the efficacy and safety of argatroban for treatment of AIS.METHODS Cochrane Library,Medline,PubMed,and Web of Science were searched to retrieve all studies associated with argatroban and AIS.Effective rate,adverse events rate,and 95%confidence intervals were calculated and pooled using metaanalysis methodology.RESULTS We only found four randomized controlled studies,comprising 354 cases with 213 in the argatroban group and 141 in the control group.Great heterogeneity was found in the four studies(c2=11.44,I2=74%,P=0.01).Subgroup analysis could not be performed because of the absence of detailed data.The two most recent studies showed acceptable heterogeneity(c2=1.56,I2=36%,P=0.21).Our analysis showed that argatroban was not more effective than the control therapy in the acute phase of ischemic stroke(Z=0.01,P=0.99).Argatroban did not increase the risk of bleeding compared with the control group(c2=0.37,I2=0%,P=0.54,Z=0.80,P=0.42).CONCLUSION Patients with AIS might not benefit from argatroban and combination therapy with argatroban does not increase bleeding tendency.

关 键 词：ARGATROBAN Anticoagulation agents Acute ischemic stroke THROMBIN THROMBOLYSIS META-ANALYSIS 

分 类 号：R743.3[医药卫生—神经病学与精神病学]