精神分裂症家族史与5－羟色胺代谢研究  

STUDY ON RELATIONSHIP BE-TWEEN FAMILY HISTORY AND SERO-TONIN METABOLISM IN PATIENTSWITH sCHIZOPHRENIA

作　　者：金卫东[1] 臧德馨[1] 曹明莉[1] 孙敬烈[1] 王高华[1] 唐珞家 史欣欣[1] 甘景梨[1] 王世尧 吕存生 谢昌峰 

机构地区：[1]解放军160医院,湖北医科大学附一医院精神科,武汉大学分析测试中心

出　　处：《中国民康医学》1995年第4期213-214,共2页Medical Journal of Chinese People’s Health

摘　　要：应用高压液相色谱对４７例散发性精神分裂症、２０例家族性精神分裂症和１０例健康正常对照组脑脊液中色氨酸、５－羟色胺和５－羟吲哚乙酸三项指标进行了测试。结果提示，家族性精神分裂症、散发性精神分裂症及正常对照组的这三项指标均无显著性差异，不支持精神分裂症有中枢５－羟色胺代谢异常的学说。he levels of tryptophan serotonin, and 5 -hydroxytryotamine (5 - HIAA) in CSF of 20 caseswith familial schizophrenia and 47 cases with spo-radic schizophrenia and 10 normal controls were de-termined by high pressure liquid chromatography(HPLC). The results showed no difference in tryp-tophan , serotonin(5-HT) , 5 -HIAA and ratio of5-HIAA/5-HT. All results were discussed.

关 键 词：精神分裂症 家族史 5-羟色胺 

分 类 号：R749.3[医药卫生—神经病学与精神病学]