Protective Effect of Radix Ginseng on Peroxidation Injury in Myocardium and Erythrocytes of Streptozocin－Induced Diabetic Rats  

作　　者：Xie Zong-chang (谢宗长)(Department of Traditional Chinese Medicine, Xiehe Hospital.Tongji Medical University, Wuhan) (430022)Qian Zhen-kun (钱振坤)and Liu Zhong-wei(柳重威)(Institute of integrated Traditional Chinese Medicine and Western Medicine.Tongji M 

出　　处：《Chinese Journal of Integrative Medicine》1995年第1期131-133,共3页中国结合医学杂志（英文版）

摘　　要：The authors have investigated the effect ot Radix Ginseng on peroxidation injury in my-ocardium and erythrocytes of streptozocin-induced diabetic rats. In the ginseng administered group (gin-seng solution 0. 2 g/200 g body weight once daily lasting 15-16 days) . there was a significant decreasein the level of fasting blood glucose and lipid peroxide in myocardium and erythrocytes, in comparison withthose of the model group (P<0. 05) . The superoxide dismutase activities in myocardium and erythrocytesof the ginseng group were increased (P<0. 05) . compared with those of the model group and the vitaminE treated group (vitamin E 10 mg/200 g.body weight once daily, lasting 15-16 days) . The results sug-gest that the mechanisms of antiperoxidation injury of ginseng might include the following: (1) loweringthe level of fasting blood glucose, decreasing monosaccharide autooxidation and partially protecting theproduction of free radicals; (2) elevating the activity of enzymatic free radical scavenger in cells, such assuperoxide dismutase, and (3) directly eliminating the superfluous free radicals.The authors have investigated the effect ot Radix Ginseng on peroxidation injury in my-ocardium and erythrocytes of streptozocin-induced diabetic rats. In the ginseng administered group (gin-seng solution 0. 2 g/200 g body weight once daily lasting 15-16 days) . there was a significant decreasein the level of fasting blood glucose and lipid peroxide in myocardium and erythrocytes, in comparison withthose of the model group (P<0. 05) . The superoxide dismutase activities in myocardium and erythrocytesof the ginseng group were increased (P<0. 05) . compared with those of the model group and the vitaminE treated group (vitamin E 10 mg/200 g.body weight once daily, lasting 15-16 days) . The results sug-gest that the mechanisms of antiperoxidation injury of ginseng might include the following: (1) loweringthe level of fasting blood glucose, decreasing monosaccharide autooxidation and partially protecting theproduction of free radicals; (2) elevating the activity of enzymatic free radical scavenger in cells, such assuperoxide dismutase, and (3) directly eliminating the superfluous free radicals.

关 键 词：Radix Ginseng STREPTOZOCIN diabetes lipid peroxide superoxide dismutase 

分 类 号：R285.5[医药卫生—中药学]