STREPTOZOCIN

作品数：10被引量：16H指数：2
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相关领域：医药卫生更多>>
相关作者：贺华关永源朱邦豪更多>>
相关机构：中山医科大学更多>>
相关期刊：《Chinese Journal of Integrative Medicine》《Acta Pharmacologica Sinica》《International Journal of Ophthalmology(English edition)》《Journal of Otology》更多>>
相关基金：国家自然科学基金更多>>
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Beneficial effects of protocatechuic acid on diabetic retinopathy in streptozocin-induced diabetic rats被引量：1
《International Journal of Ophthalmology(English edition)》2023年第6期855-862,共8页Ling Wan Jun Li Wei-Bai Chen Guo-Qiang Wu 
Supported by Model Construction of Regional Prevention and Treatment of Diabetic Retinopathy,Sichuan Science and Technology Support Program (No.2016FZ0091)。
·AIM:To determine the effects of protocatechuic acid(PCA)on streptozocin-induced diabetic retinopathy(DR)in rats.·METHODS:Wistar rats were given a 50 mg/kg intraperitoneal injection of streptozocin to induce diabete...
关键词：diabetic retinopathy STREPTOZOCIN protocatechuic acid oxidative stress vascular endothelial growth factor 
S6B-3 Intracerebroventricular Streptozocin-Induced Alzheimer’s Disease-Like Sleep Disorders:Role of the GABAergic System in the Parabrachial Complex
《神经药理学报》2018年第4期96-97,共2页CUI Su-ying SONG Jin-zhi CUI Xiang-yu HU Xiao DING Hui YE Hui ZHANG Yong-he 
Aim:Sleep disorders are common in Alzheimer’s disease(AD)and assumed to directly influence cognitive function and progression of the disease.The present study evaluated sleep characteristics in a rat model of AD that...
关键词：Alzheimer’s disease Sleep DISORDERS GABA STREPTOZOCIN Parabrachial nucleus 
Antihyperglycemic effect of methanol extract of Tamarix aphylla L. Karst (Saltcedar) in streptozocin–nicotinamide induced diabetic rats
《Asian Pacific Journal of Tropical Biomedicine》2017年第7期619-623,共5页rooh ullah shafiq ahmed tariq naeem khan nawaz sharif zia ud din khalid mansoor 
supported by Institute of Basic Medical Sciences, Khyber Medical University with grant no. of 06472414
Objective: To evaluate the antihyperglycemic potential of Tamarix aphylla(T. aphylla)leaves in STZ–NIC induced diabetes in Wister Albino rats.Methods: Acute toxicity study was done to check the toxicity of T. aphylla...
关键词：Tamarix aphylla leaves Diabetes Streptozotocin Antidiabetic potential Insulin secretion 
Protective effects of total triterpenoids extracts from Cyclocarya paliurus(Batal.)Iljinskaja on STZ-stimulated INS-1 cells through regulating of autophagy and apoptosis被引量：2
《中国药理学与毒理学杂志》2016年第10期1057-1058,共2页ZHOU Qin SHI Meng-qiong Wu Xue-zhi HE Hai-bo LIU Ying QIN Hui-lin ZHANG Yong-feng 
The project supported by National Natural and Science Foundation of China(81341141);Yichang Qingqianliu Biotechnology Co.,Ltd.(SDHZ201602);Science and Technology Bureau of Yichang city(A15301-25)
OBJECTIVE To explore the protective effects of total triterpenoids extracts from Cyclocarya paliurus(Batal.)Iljinskaja on STZ-stimulated INS-1 cells through regulating of autophagy and apoptosis.METHODS INS-1cells wer...
关键词：total triterpenoids extracts from Cyclocarya paliurus(Batal.) Iljinskaja INS-1 cells STREPTOZOCIN AUTOPHAGY APOPTOSIS 
EFFECTS OF JIANG TANG FANG LONG FORMULA ON INSULIN PRODUCTION AND FUNCTION IN AN ANIMAL MODEL OF DIABETIC HEARING LOSS
《Journal of Otology》2013年第2期88-90,共3页YANG Yunxia LI Ruiyu JING Jianmei ZHANG Yanzhuo LI Meng LI Bin FENG Jinping LI Li LI Huizhen 
Objective To study the influence of Jiang Tang Fang Long formula on insulin production and function in an animal model of diabetic hearing loss. Methods Wistar rats (n=60) were randomly divided into 6 groups (10 in ea...
关键词：Jiang Tang Fang Long formula diabetes DEAFNESS Wistar rats STREPTOZOCIN 
Effect of Xixin decoction on O-linked N-acetylglucosamine Glycosylation of tau proteins in rat brain with sporadic Alzheimer disease被引量：3
《Journal of Traditional Chinese Medicine》2013年第3期367-372,共6页Yongchang Diwu Jinzhou Tian Jing Shi 
Supported by National Nature Science Foundation(No.30973738)
OBJECTIVE： To study the effects of Xixin decoction （XXD） on O-linked N-acetylglucosamine （O-GIcNAc） glycosylation of tau proteins in rat brain with spo- radic Alzheimer disease （SAD）, and discuss its possi- ble...
关键词：Alzheimer Disease Injections  intraven-tricular STREPTOZOCIN Tau proteins O-linkedN-acetylglucosamine GLYCOSYLATION Xixin decoc-tion 
Direct transfer of A20 gene into pancreas protected mice from streptozotocin-induced diabetes被引量：9
《Acta Pharmacologica Sinica》2004年第6期721-726,共6页Lu-yangYU BoLIN Zhen-linZHANG Li-heGUO 
Project supported by the State Key Basic R&D Programme"973" (NoG1999053905).
AIM: To investigate the efficiency of transfer of A20 gene into pancreas against STZ-induced diabetes. METHODS: PVP-plasmid mixture was directly transferred into the pancreatic parenchyma 2 ...
关键词：ADENOVIRIDAE STREPTOZOCIN insulin-dependent diabetes mellitus gene therapy nitric oxide glucose AMYLASES reversed transcriptase polymerase chain reaction Western blotting 
Contractile responses of diabetic rat aorta to phenylephrine at different stages of diabetic duration
《Acta Pharmacologica Sinica》2001年第5期65-69,共5页朱邦豪 关永源 闽军 贺华 
Project supported by the Science Foundation of Guangdong Province (99M01304G);the National Natural Science Foundation of China (No 39970849)
AIM: To investigate the time-dependent changes in contractile responses of aorta to phenylephrine (Phe) in diabetic rats and age-matched control, and its possible mechanism. METHODS: At stages of 2-, 6-, and 12-week d...
关键词：experimental diabetes mellitus thoracic aorta PHENYLEPHRINE STREPTOZOCIN cyclopiazonic acid CALCIUM 
Effects of Scutellarein on diabetic rat aorta被引量：1
《Acta Pharmacologica Sinica》2000年第4期353-356,共4页朱邦豪 关永源 贺华 林默君 
Project supported by the Returned Scholar Foundation of the National Education Committee of China;the National Natural Science Foundation (№ 39770858) and the Post-doctoral Foundation of China
AIM: To study the effect of Scutellarein (Scu) on the diabetic rat aorta. METHODS: Contractile responses to phenylepherine and endothelium-dependent relaxation responses to acetylcholine (ACh) in rat aorta were invest...
关键词：SCUTELLAREIN experimental diabetes mellitus thoracic aorta vascular endothelium phenyle- pherine ACETYLCHOLINE STREPTOZOCIN VASOCONSTRICTION VASODILATION 
Protective Effect of Radix Ginseng on Peroxidation Injury in Myocardium and Erythrocytes of Streptozocin－Induced Diabetic Rats
《Chinese Journal of Integrative Medicine》1995年第1期131-133,共3页Xie Zong-chang (谢宗长)(Department of Traditional Chinese Medicine, Xiehe Hospital.Tongji Medical University, Wuhan) (430022)Qian Zhen-kun (钱振坤)and Liu Zhong-wei(柳重威)(Institute of integrated Traditional Chinese Medicine and Western Medicine.Tongji M 
The authors have investigated the effect ot Radix Ginseng on peroxidation injury in my-ocardium and erythrocytes of streptozocin-induced diabetic rats. In the ginseng administered group (gin-seng solution 0. 2 g/200 g...
关键词：Radix Ginseng STREPTOZOCIN diabetes lipid peroxide superoxide dismutase 
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