Beneficial effects of protocatechuic acid on diabetic retinopathy in streptozocin-induced diabetic rats  

作　　者：Ling Wan Jun Li Wei-Bai Chen Guo-Qiang Wu 

机构地区：[1]Department of Ophthalmology,Sichuan Provincial People’s Hospital,University of Electronic Science and Technology of China,Chengdu 610072,Sichuan Province,China [2]Department of Ophthalmology,Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital,Chengdu 610072,Sichuan Province,China [3]Department of Ophthalmology,the First People’s Hospital of Lanzhou City,Lanzhou 730050,Gansu Province,China

出　　处：《International Journal of Ophthalmology(English edition)》2023年第6期855-862,共8页国际眼科杂志（英文版）

基　　金：Supported by Model Construction of Regional Prevention and Treatment of Diabetic Retinopathy,Sichuan Science and Technology Support Program (No.2016FZ0091)。

摘　　要：·AIM:To determine the effects of protocatechuic acid(PCA)on streptozocin-induced diabetic retinopathy(DR)in rats.·METHODS:Wistar rats were given a 50 mg/kg intraperitoneal injection of streptozocin to induce diabetes.Animals were assigned randomly one of four groups(8 rats per group):control,diabetic,diabetic plus PCA(25 mg/kg·d),and diabetic plus PCA(50 mg/kg·d).After inducing diabetes,treatments were started one week later and continued for eight weeks.After the experiment,the rats were sacrificed,and their retinas were taken for biochemical and molecular analysis.·RESULTS:PCA administration diminished the blood glucose and glycated haemoglobin levels relative to the diabetic group.In diabetic rats,PCA lowered elevated levels of advanced glycosylated end products(AGEs)and receptor for AGEs(RAGE).In the retina of diabetic rats,PCA effectively decreased inflammatory cytokine,nuclear factor-κB,tumour necrosis factor-α,interleukin-1β,and vascular endothelial growth factor,and increased antioxidant markers glutathione,superoxide dismutase,and catalase.·CONCLUSION:The protective benefits of PCA against DR may be attributable to its suppression of the AGEs and RAGE and its antioxidant and anti-inflammatory properties.

关 键 词：diabetic retinopathy STREPTOZOCIN protocatechuic acid oxidative stress vascular endothelial growth factor 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]