Effects of Scutellarein on diabetic rat aorta  

野黄芩甙元对糖尿病大鼠主动脉的影响(英文)

作　　者：朱邦豪[1] 关永源[1] 贺华[1] 林默君 

机构地区：[1]中山医科大学药理教研室 [2]CMB Visiting Scholar from Department of Physiology,Pujian Medical University

出　　处：《Acta Pharmacologica Sinica》2000年第4期353-356,共4页中国药理学报（英文版）

基　　金：Project supported by the Returned Scholar Foundation of the National Education Committee of China;the National Natural Science Foundation (№ 39770858) and the Post-doctoral Foundation of China

摘　　要：AIM: To study the effect of Scutellarein (Scu) on the diabetic rat aorta. METHODS: Contractile responses to phenylepherine and endothelium-dependent relaxation responses to acetylcholine (ACh) in rat aorta were investigated after streptozocin-induced 6-wk diabetes, Scu-treat-ed streptozocin-induced diabetes, and in age-matched control in vitro. RESULTS: 1) Endothelium-dependent relaxation to ACh in diabetic rats was decreased (P <0.01) compared with age-matched control. 2) Contractile responses to phenylepherine were increased ( P < 0.01) in diabetic rats. 3) The dietary supplement of 0.5 % Scu starting from 1-wk diabetes induction prevented endothelial dysfunction (P < 0.01), but the contractile responses to phenylepherine were further increased. CONCLUSION: Scu prevented vascular endothelial dysfunction in diabetic rats, and also potentiated the contraction induced by phenylepherine目的:研究野黄芩甙元对糖尿病大鼠血管合并症的预防作用。方法:利用平滑肌条离体研究装置。结果:在第六周的糖尿病大鼠主动脉:1)乙酰胆碱引起的内膜依赖性舒张作用较对照明显减弱(P<0.01);2)苯肾上腺素引起的收缩反应较对照明显增加,最大收缩增加约40％(P<0.01);3)糖尿病大鼠服用含0.5％的野黄芩甙元的饮水后,乙酰胆碱引起的内膜依赖性舒张作用较糖尿病组明显增加(P<0.01),但是,苯肾上腺素引起的收缩反应增加更显著,最大收缩较对照增加约80％(P<0.01)。结论:野黄芩甙元对糖尿病引起的血管内膜功能损害有防护作用,也可增强苯肾上腺素引起的收缩。

关 键 词：SCUTELLAREIN experimental diabetes mellitus thoracic aorta vascular endothelium phenyle- pherine ACETYLCHOLINE STREPTOZOCIN VASOCONSTRICTION VASODILATION 

分 类 号：R285[医药卫生—中药学]