ADENOVIRIDAE

作品数：18被引量：93H指数：6
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相关领域：医药卫生更多>>
相关作者：董蔚张端珍文应峰盖鲁粤范瑞云更多>>
相关机构：第二军医大学中国人民解放军总医院杜兰大学武汉大学更多>>
相关期刊：《国际耳鼻咽喉头颈外科杂志》《Journal of Microbiology and Immunology》《Chinese Journal of Traumatology》《Acta Pharmacologica Sinica》更多>>
相关基金：国家自然科学基金教育部留学回国人员科研启动基金更多>>
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Preterminal protein,the achilles heel of adenoviridae:Implications for adenoviral infections
《World Journal of Pharmacology》2024年第2期1-9,共9页Harold A Walsh 
BACKGROUND Adenoviruses pose a serious health risk particularly in the absence of any clinically approved treatment.As adenoviral infections are quite frequent and recent outbreaks manifest more virulent variant strai...
关键词：Thomsen-Friedenreich antigen ADENOVIRAL Preterminal protein Spodoptera frugiperda cells Protein priming mechanism Glycosylation 
Adenovirus-mediated and tumor-specific transgene expression of the sodium-iodide symporter from the human telomerase reverse transcriptase promoter enhances killing of lung cancer cell line in vitro被引量：7
《Chinese Medical Journal》2010年第15期2070-2076,共7页SHI Yi-zhen ZHANG Jun LIU Zeng-li DU Shou-ying SHEN Yong-mei 
This work was supported by Project of Natural Science Foundation of Jiangsu Province （NO. BK2008164）.
Background The sodium-iodide symporter （NIS） protein can mediate the active radioiodine uptake.The human telomerase reverse transcriptase （hTERT） promoter is known to be selectively reactivated in majority of tumo...
关键词：sodium-iodide symporter INFECTION ADENOVIRIDAE iodine radioisotopes colony-forming units assay 
基因治疗中的腺病毒载体
《国际耳鼻咽喉头颈外科杂志》2007年第1期13-15,共3页丛铁川 秦永 
国家自然科学基金资助项目（C030310）
通过对腺病毒的纤维蛋白、五邻体蛋白和六邻体蛋白的研究,改善了腺病毒载体对肿瘤细胞的靶向性。利用免疫抑制剂抑制、改造腺病毒壳粒蛋白的抗原表位或尽量减少腺病毒DNA中非必需基因的表达,减少了腺病毒载体的免疫反应。腺病毒载体在...
关键词：腺病毒科(Adenoviridae) 基因疗法(Gene Therapy) 
Immunogenicity of the recombinant adenovirus type 5 vector with type 35 fiber containing HIV-1 gag gene
《Journal of Microbiology and Immunology》2006年第4期306-312,共7页XIN LEI LIU SHUNAG QING YU XIA FENG XIAO LI WANG HONG MEI LIU XIAO MEI ZHANG HONG XIA LI LING ZHOU YI ZENG 
The immune efficiency of a recombinant adenovirus type 5 with type 35 fiber containing HIV-1 gag gene （rAd5/F35-mod. gag） was investigated in BALB/c mice, in which the rAd5/F35-mod, gag was firstly identified with P...
关键词：H1V-1 AIDS vaccines Adenoviridae 
The effect of adenovirus expressing wild-type p53 on 5-fluorouracil chemosensitivity is related to p53 status in pancreatic cancer cell lines被引量：14
《World Journal of Gastroenterology》2004年第24期3583-3589,共7页Sven Eisold Michael Linnebacher EduardRyschich DaliborAntolovic UlfHinz Ernst Klar Jan Schmidt 
AIM:There are conflicting data about p53 function on cellular sensitivity to the cytotoxic action of 5-fluorouracil (5-FU). Therefore the objective of this study was to determine the combined effects of adenovirus-med...
关键词：ADENOVIRIDAE Adult Animals Antimetabolites  Antineoplastic Apoptosis Cell Division Cell Line  Tumor Combined Modality Therapy Drug Resistance  Neoplasm Female Fluorouracil Gene Expression Regulation  Neoplastic Gene Therapy Humans In Vitro Male Pancreatic Neoplasms RATS Rats  Inbred Lew Transduction  Genetic Tumor Suppressor Protein p53 
Direct transfer of A20 gene into pancreas protected mice from streptozotocin-induced diabetes被引量：9
《Acta Pharmacologica Sinica》2004年第6期721-726,共6页Lu-yangYU BoLIN Zhen-linZHANG Li-heGUO 
Project supported by the State Key Basic R&D Programme"973" (NoG1999053905).
AIM: To investigate the efficiency of transfer of A20 gene into pancreas against STZ-induced diabetes. METHODS: PVP-plasmid mixture was directly transferred into the pancreatic parenchyma 2 ...
关键词：ADENOVIRIDAE STREPTOZOCIN insulin-dependent diabetes mellitus gene therapy nitric oxide glucose AMYLASES reversed transcriptase polymerase chain reaction Western blotting 
Adeno-associated virus mediated endostatin gene therapy in combination with topoisomerase inhibitor effectively controls liver tumor in mouse model被引量：6
《World Journal of Gastroenterology》2004年第8期1191-1197,共7页SungYiHong MyunHeeLee WooJinHyung SungHoonNoh SeungHoChoi Kyung Sup Kim HyunCheolJung JaeKyungRoh 
Supported by a faculty research grant of Yonsei University College of Medicine for 2002,No.2002-06
AIM:rAAV mediated endostatin gene therapy has been examined as a new method for treating cancer.However, a sustained and high protein delivery is required to achieve the desired therapeutic effects.We evaluated the im...
关键词：ADENOVIRIDAE Animals Antineoplastic Agents Antineoplastic Agents  Phytogenic CAMPTOTHECIN Carcinoma  Hepatocellular Cell Line  Tumor Combined Modality Therapy DNA Topoisomerases inhibitors Drug Synergism ENDOSTATINS Endothelium  Vascular Enzyme Inhibitors ETOPOSIDE Gene Expression Gene Therapy Humans Liver Neoplasms Mice Research Support  Non-U.S. Gov't SARCOMA Survival Rate Umbilical Veins 
Expression of adenovirus-mediated neurotrophin-3 gene in Schwann cells of sciatic nerve in rats被引量：10
《Chinese Journal of Traumatology》2003年第2期75-80,共6页朱锦宇 黄耀添 朱庆生 吕荣 
Objective: To investigate the expression of neurotrophin-3 (NT-3) gene in Schwann cells of rat sciatic nerve introduced by an adenovirus vector in vivo. Methods: A recombinant adenovirus vector for NT-3 (Ad-NT-3) was ...
关键词：Gene expression ADENOVIRIDAE Schwann cells Sciatic nerve NEUROTROPHIN-3 
Adenoviral mediated suicide gene transfer in the treatment of pancreatic cancer
《Chinese Medical Journal》2002年第8期1205-1208,153,共4页潘雪 李兆申 许国铭 崔龙 张素贞 龚燕芳 屠振兴 
ThisworkwassurpportedbyScientificCommitteeFoundationofShanghai (No 9941190 44 )
OBJECTIVE: To determine the efficacy of adenovirus　mediated suicide gene transduction combined with prodrug 5-fluorocytosine (5FC) as a therapeutic protocol for pancreatic cancer. METHODS: Cytosine Deaminase(CD) gene...
关键词：Gene Therapy ADENOVIRIDAE Animals Cytosine Deaminase Gene Transfer Techniques Genetic Vectors Humans MICE Mice  Inbred BALB C Nucleoside Deaminases Pancreatic Neoplasms Research Support  Non-U.S. Gov't 
Gene-viral vectors: a promising way to target tumor cells and express anticancer genes simultaneously
《Chinese Medical Journal》2002年第8期1213-1217,154-155,共5页钱其军 岑信棠 车小燕 徐建国 薛惠斌 崔贞福 朱斌 吴孟超 
ThisworkwassupportedbytheKeyNaturalScientificFoundationofChina(No 39730440)KeyModernBiologyandNewDrugDevelopmentFoundationofShanghaiNo984319119)andShanghaiYouthScientificandTechnologicalRisingSunPlan(No 99QB14 0 46)
OBJECTIVE: To develop a new kind of vector system called gene-viral vector, which combines the advantages of gene and virus therapies. METHODS: Using recombinant technology, an anti-tumor gene was inserted into the ge...
关键词：ADENOVIRIDAE Adenovirus E1A Proteins Adenovirus E1B Proteins Gene Therapy Genetic Vectors Humans INTERLEUKIN-12 Neoplasms Recombination  Genetic Research Support  Non-U.S. Gov't Tumor Cells  Cultured Virus Replication 
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