supported by the National Natural Science Foundation of China(82071399);National Key Research and Development Program of China(2023YFC2412504,2016YFC1101502);Key Research and Development Program of Hunan Province(2021DK2003,2021SK2016).
Induced pluripotent stem cells(iPSCs)can be personalized and differentiated into neural stem cells(NSCs),thereby effectively providing a source of transplanted cells for spinal cord injury(SCI).To further improve the ...
supported by grants from the National Key R&D Program of China,No.2017YFA0104704(to BQL);the Young Elite Scientist Sponsorship Program(YESS)by China Association for Science and Technology(CAST),No.2018QNRC001(to BQL);the Fundamental Research Funds for the Central Universities,China,No.18ykpy38(to BQL);the National Natural Science Foundation of China,Nos.81971157(to BQL),81891003(to YSZ).
Axon regeneration and remyelination of the damaged region is the most common repair strategy for spinal cord injury.However,achieving good outcome remains difficult.Our previous study showed that porcine decellularize...
the Chinese National Natural Science Foundation of China(81891003);the National Key R&D Program of China(2017YFA0104700)and the 111 Project for Academic Exchange Program(B13037)to Y.S.Zeng;the Foundation of Guangdong Province(2017B020210012)to Y.S.Zeng and X.Zeng;the Co-innovation Foundation of Guangzhou City(201704020221)to Y.S.Zeng,X.Zeng,and G.Li;the Start-up Foundation of Guangdong Province(Grant No.2018A030310113)to G.Li.
The mechanism underlying neurogenesis during embryonic spinal cord development involves a specific ligand/receptor interaction,which may be help guide neuroengineering to boost stem cell-based neural regeneration for ...
funded by Egyptian Cultural and Educational Bureau in London,Egyptian mission sector and ministry of higher education in Egypt(grant No.GAM2649)。
Dental pulp stem cells(DPSCs) secrete neurotrophic factors which may play an important therapeutic role in neural development, maintenance and repair. To test this hypothesis, DPSCs-conditioned medium(DPSCs-CM) was co...
supported in part by NIH 1R01100531,1R01 NS103481,Merit Review Award I01 BX002356,I01 BX003705,I01 RX002687 from the USA Department of Veterans Affairs,Mari Hulman George Endowment Funds(to XMX)。
Traumatic spinal cord injury(SCI)leads to chronic locomotor impairment and disability.Unfortunately,there are no effective treatments currently available for SCI patients(Bradbury and Burnside,2019).Developing novel r...
supported by the research start-up and the MWU’s intramural grant(to MF);the Italian MURST-MIUR foundation(to SG and IP)
Neurotrophins play a major role in the regulation of neuronal growth such as neurite sprouting or regeneration in response to nerve injuries. The role of nerve growth factor, neurotrophin-3, and brain-derived neurotro...
funded by the Brain Research Trust,the Rosetrees Trust and the International Spinal Research Trust;a grant from the European Research Council under the European Union’s Seventh Framework Programme(FP/2007-2013);ERC Grant Agreement n.309731;by a Research Councils UK Academic Fellowship;by the Medical Research Council(MRC)and the British Pharmacological Society(BPS)’s Integrative Pharmacology Fund;supported by the Dowager Countess Eleanor Peel Trust;a Capacity Building Award in Integrative Mammalian Biology funded by the Biotechnology and Biological Sciences Research Council,BPS;Higher Education Funding Council for England,Knowledge Transfer Partnerships,MRC and Scottish Funding Council
Neurotrophin-3 (NT3) is a growth factor found in many body tissues including the heart, intestines, skin, nervous system and in skeletal muscles including muscle spindles (Murase et al., 1994). NT3 is required for the...
Objective:To study the effects of neurotrophin-3 (NT-3) intervention on bone marrow mesenchymal stem cell osteoblast differentiation as well as cell proliferation and apoptosis. Methods: Bone marrow mesenchymal stem c...