NEUROTROPHIN-3

作品数:38被引量:115H指数:7
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相关领域:医药卫生更多>>
相关作者:吴军王献章孙天胜任继鑫李诗雅更多>>
相关机构:北京军区总医院空军军医大学(第四军医大学)安徽医科大学第四附属医院新乡医学院第一附属医院更多>>
相关期刊:《实用医学杂志》《Science Bulletin》《Journal of Hainan Medical University》《Bioactive Materials》更多>>
相关基金:国家自然科学基金高等学校学科创新引智计划河南省医学科技攻关计划项目更多>>
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Neurotrophin-3、LncRNA H19与小儿癫痫持续状态严重程度的关系及对预后预测效能研究
《疑难病杂志》2024年第10期1210-1215,共6页何米兰 王立和 赵国晓 李诗雅 夏勇波 
山西省卫健委科研课题项目(2023151)。
目的探讨神经营养因子-3(Neurotrophin-3)、长链非编码核糖核酸H19(LncRNA H19)与小儿癫痫持续状态(SE)严重程度的关系及对预后预测效能。方法选取2020年1月—2023年12月山西医科大学附属运城市中心医院儿内科收治的SE患儿152例为SE组,...
关键词:癫痫持续状态 神经营养因子-3 长链非编码核糖核酸H19 严重程度 预后 诊断效能 儿童 
Construction of functional neural network tissue combining CBD-NT3-modified linear-ordered collagen scaffold and TrkC-modified iPSC-derived neural stem cells for spinal cord injury repair被引量:3
《Bioactive Materials》2024年第5期242-258,共17页Zhaoping Wu Yi Zhou Xianglin Hou Weidong Liu Wen Yin Lei Wang Yudong Cao Zhipeng Jiang Youwei Guo Quan Chen Wen Xie Ziqiang Wang Ning Shi Yujun Liu Xiang Gao Longlong Luo Jianwu Dai Caiping Ren Xingjun Jiang 
supported by the National Natural Science Foundation of China(82071399);National Key Research and Development Program of China(2023YFC2412504,2016YFC1101502);Key Research and Development Program of Hunan Province(2021DK2003,2021SK2016).
Induced pluripotent stem cells(iPSCs)can be personalized and differentiated into neural stem cells(NSCs),thereby effectively providing a source of transplanted cells for spinal cord injury(SCI).To further improve the ...
关键词:Spinal cord injury Induced pluripotent stem cells LOCS Neural network tissue NEUROTROPHIN-3 
Decellularized optic nerve functional scaffold transplant facilitates directional axon regeneration and remyelination in the injured white matter of the rat spinal cord被引量:7
《Neural Regeneration Research》2021年第11期2276-2283,共8页Yu-Rong Bai Bi-Qin Lai Wei-Tao Han Jia-Hui Sun Ge Li Ying Ding Xiang Zeng Yuan-Huan Ma Yuan-Shan Zeng 
supported by grants from the National Key R&D Program of China,No.2017YFA0104704(to BQL);the Young Elite Scientist Sponsorship Program(YESS)by China Association for Science and Technology(CAST),No.2018QNRC001(to BQL);the Fundamental Research Funds for the Central Universities,China,No.18ykpy38(to BQL);the National Natural Science Foundation of China,Nos.81971157(to BQL),81891003(to YSZ).
Axon regeneration and remyelination of the damaged region is the most common repair strategy for spinal cord injury.However,achieving good outcome remains difficult.Our previous study showed that porcine decellularize...
关键词:axonal regeneration decellularized optic nerve directional regeneration functional scaffold microenvironment NEUROTROPHIN-3 optic nerve REMYELINATION Schwann cells tissue engineering white matter injury 
An NT-3-releasing bioscaffold supports the formation of TrkC-modified neural stem cell-derived neural network tissue with efficacy in repairing spinal cord injury被引量:13
《Bioactive Materials》2021年第11期3766-3781,共16页Ge Li Bao Zhang Jia-hui Sun Li-yang Shi Meng-yao Huang Li-jun Huang Zi-jing Lin Qiong-yu Lin Bi-qin Lai Yuan-huan Ma Bin Jiang Ying Ding Hong-bo Zhang Miao-xin Li Ping Zhu Ya-qiong Wang Xiang Zeng Yuan-shan Zeng 
the Chinese National Natural Science Foundation of China(81891003);the National Key R&D Program of China(2017YFA0104700)and the 111 Project for Academic Exchange Program(B13037)to Y.S.Zeng;the Foundation of Guangdong Province(2017B020210012)to Y.S.Zeng and X.Zeng;the Co-innovation Foundation of Guangzhou City(201704020221)to Y.S.Zeng,X.Zeng,and G.Li;the Start-up Foundation of Guangdong Province(Grant No.2018A030310113)to G.Li.
The mechanism underlying neurogenesis during embryonic spinal cord development involves a specific ligand/receptor interaction,which may be help guide neuroengineering to boost stem cell-based neural regeneration for ...
关键词:NEUROTROPHIN-3 Tropomyosin kinase receptor C Self-organization Neural network tissue Spinal cord injury 
Dental pulp stem cells stimulate neuronal differentiation of PC12 cells被引量:4
《Neural Regeneration Research》2021年第9期1821-1828,共8页Nessma Sultan Laila E.Amin Ahmed R.Zaher Mohammed E.Grawish Ben A.Scheven 
funded by Egyptian Cultural and Educational Bureau in London,Egyptian mission sector and ministry of higher education in Egypt(grant No.GAM2649)。
Dental pulp stem cells(DPSCs) secrete neurotrophic factors which may play an important therapeutic role in neural development, maintenance and repair. To test this hypothesis, DPSCs-conditioned medium(DPSCs-CM) was co...
关键词:brain-derived neurotrophic factor conditioned medium dental pulp stem cell glial cell line-derived nerve growth factor neurite outgrowth neurotrophic factor NEUROTROPHIN-3 phaeochromocytoma PC12 cell 
Neurotrophin-3-mediated locomotor recovery: a novel therapeutic strategy targeting lumbar neural circuitry after spinal cord injury被引量:6
《Neural Regeneration Research》2020年第12期2241-2242,共2页Qi Han Xiao-Ming Xu 
supported in part by NIH 1R01100531,1R01 NS103481,Merit Review Award I01 BX002356,I01 BX003705,I01 RX002687 from the USA Department of Veterans Affairs,Mari Hulman George Endowment Funds(to XMX)。
Traumatic spinal cord injury(SCI)leads to chronic locomotor impairment and disability.Unfortunately,there are no effective treatments currently available for SCI patients(Bradbury and Burnside,2019).Developing novel r...
关键词:LUMBAR NEURAL INJURY 
Role of neurotrophic factors in enhancing linear axonal growth of ganglionic sensory neurons in vitro被引量:3
《Neural Regeneration Research》2020年第9期1732-1739,共8页Michele Fornaro Alessia Giovannelli Angelica Foggetti Luisa Muratori Stefano Geuna Giorgia Novajra Isabelle Perroteau 
supported by the research start-up and the MWU’s intramural grant(to MF);the Italian MURST-MIUR foundation(to SG and IP)
Neurotrophins play a major role in the regulation of neuronal growth such as neurite sprouting or regeneration in response to nerve injuries. The role of nerve growth factor, neurotrophin-3, and brain-derived neurotro...
关键词:brain-derived neurotrophic factor DIRECTIONALITY dorsal root ganglia explant nerve growth factor nerve regeneration neurite growth enhancement neurotrophic factors NEUROTROPHIN-3 sensory neurons TORTUOSITY 
Delayed peripheral treatment with neurotrophin-3 improves sensorimotor recovery after central nervous system injury
《Neural Regeneration Research》2019年第10期1703-1704,共2页Sotiris G.Kakanos Lawrence D.F.Moon 
funded by the Brain Research Trust,the Rosetrees Trust and the International Spinal Research Trust;a grant from the European Research Council under the European Union’s Seventh Framework Programme(FP/2007-2013);ERC Grant Agreement n.309731;by a Research Councils UK Academic Fellowship;by the Medical Research Council(MRC)and the British Pharmacological Society(BPS)’s Integrative Pharmacology Fund;supported by the Dowager Countess Eleanor Peel Trust;a Capacity Building Award in Integrative Mammalian Biology funded by the Biotechnology and Biological Sciences Research Council,BPS;Higher Education Funding Council for England,Knowledge Transfer Partnerships,MRC and Scottish Funding Council
Neurotrophin-3 (NT3) is a growth factor found in many body tissues including the heart, intestines, skin, nervous system and in skeletal muscles including muscle spindles (Murase et al., 1994). NT3 is required for the...
关键词:Neurotrophin-3(NT3) TISSUES including the heart Boyce and Mendell 
Effects of neurotrophin-3 intervention on on bone marrow mesenchymal stem cell osteoblast differentiation as well as cell proliferation and apoptosis
《Journal of Hainan Medical University》2018年第16期1-4,共4页Bin Xie Rui Chang 
Objective:To study the effects of neurotrophin-3 (NT-3) intervention on bone marrow mesenchymal stem cell osteoblast differentiation as well as cell proliferation and apoptosis. Methods: Bone marrow mesenchymal stem c...
关键词:NEUROTROPHIN-3 Bone MARROW MESENCHYMAL stem cell OSTEOBLAST differentiation Proliferation Apoptosis 
NT-3转染骨髓间充质干细胞对脊髓缺血再灌注的机制研究
《实用医学杂志》2016年第19期3160-3164,共5页宗海斌 董玉珍 
河南省医学科技攻关计划项目课题(编号:201403141)
目的:研究神经营养素-3(NT-3)转染骨髓间充质干细胞(BMSCs)移植对脊髓缺血再灌注损伤的作用机制。方法:将NT-3转染入BMSCs后移植于80只脊髓缺血再灌注损伤大鼠,分为4组:假手术(Sham)组、对照(NS)组、BMSCs组和NT-3+BMSCs组,观察损伤大鼠...
关键词:神经营养素-3 骨髓间充质干细胞 神经元凋亡 脊髓缺血再灌注损伤 机制 NEUROTROPHIN-3 
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