Neurotrophin-3-mediated locomotor recovery: a novel therapeutic strategy targeting lumbar neural circuitry after spinal cord injury  

作　　者：Qi Han Xiao-Ming Xu 

机构地区：[1]Spinal Cord and Brain Injury Research Group,Stark Neurosciences Research Institute,Department of Neurological Surgery,Indiana University School of Medicine,Indianapolis,IN,USA

出　　处：《Neural Regeneration Research》2020年第12期2241-2242,共2页中国神经再生研究（英文版）

基　　金：supported in part by NIH 1R01100531,1R01 NS103481,Merit Review Award I01 BX002356,I01 BX003705,I01 RX002687 from the USA Department of Veterans Affairs,Mari Hulman George Endowment Funds(to XMX)。

摘　　要：Traumatic spinal cord injury(SCI)leads to chronic locomotor impairment and disability.Unfortunately,there are no effective treatments currently available for SCI patients(Bradbury and Burnside,2019).Developing novel repair interventions to mitigate the devastating nature of SCI and translating them clinically are urgent medical needs to improve the quality of life of patients with SCI.The lumbar spinal motoneurons(MNs)are the final common pathway for hindlimb locomotion since all neural activities that influence hindlimb movement converging upon these neurons.

关 键 词：LUMBAR NEURAL INJURY 

分 类 号：R651.2[医药卫生—外科学]