INTERLEUKIN-12

作品数：70被引量：482H指数：11
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相关领域：医药卫生更多>>
相关作者：陈佳瑜葛正龙许洁王胜军季晓辉更多>>
相关机构：第二军医大学学研究院遵义医学院镇江医学院更多>>
相关期刊：《World Journal of Clinical Cases》《浙江医学》《国际感染病学（电子版）》《中华麻醉学杂志》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金上海市青年科技启明星计划更多>>
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Evaluating the role of interleukin-2 and interleukin-12 in pediatric patients with concurrent Mycoplasma pneumoniae and Epstein-Barr virus infections
《World Journal of Clinical Cases》2024年第23期5346-5353,共8页Yan-Ping Hao 
BACKGROUND Mycoplasma pneumoniae(MP)frequently causes respiratory infections in children,whereas Epstein-Barr virus(EBV)typically presents subclinical manifestations in immunocompetent pediatric populations.The incide...
关键词：INTERLEUKIN-2 INTERLEUKIN-12 Mycoplasma pneumonia Epstein-Barr virus COINFECTION 
Approach to loss of response to advanced therapies in inflammatory bowel disease被引量：1
《World Journal of Gastroenterology》2024年第22期2902-2919,共18页Nikil Vootukuru Abhinav Vasudevan 
BACKGROUND Remarkable progress over the last decade has equipped clinicians with many options in the treatment of inflammatory bowel disease.Clinicians now have the unique opportunity to provide individualized treatme...
关键词：Inflammatory bowel disease Ulcerative colitis CROHN BIOLOGICS Interleukin-12 and interleukin-23 inhibitors Alpha-beta7-integrin inhibitors Janus kinase inhibitors Sphingosine-1-phosphate receptor modulators 
Newcastle disease virus suppresses antigen presentation via inhibiting IL-12 expression in dendritic cells
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第3期254-270,共17页Fulong NAN Wenlong NAN Xin YAN Hui WANG Shasha JIANG Shuyun ZHANG Zhongjie YU Xianjuan ZHANG Fengjun LIU Jun LI Xiaoqiong ZHOU Delei NIU Yiquan LI Wei WANG Ning SHI Ningyi JIN Changzhan XIE Xiaoni CUI He ZHANG Bin WANG Huijun LU 
As a potential vectored vaccine,Newcastle disease virus(NDV)has been subject to various studies for vaccine development,while relatively little research has outlined the immunomodulatory effect of the virus in antigen...
关键词：Newcastle disease virus Dendritic cells Interleukin-12(IL-12) T cells IMMUNOSUPPRESSION 
Altered expression of miR-125a and dysregulated cytokines in systemic lupus erythematosus: Unveiling diagnostic and prognostic markers
《World Journal of Experimental Medicine》2023年第5期102-114,共13页Tagreed Qassim Alsbihawi Mojtaba Zare Ebrahimabad Fakhri Sadat Seyedhosseini Homa Davoodi Nafiseh Abdolahi Alireza Nazari Saeed Mohammadi Yaghoub Yazdani 
the Department of Research and Technology at Golestan University of Medical Sciences,No.113017.
BACKGROUND Systemic lupus erythematosus(SLE)is a chronic autoimmune disorder impacting multiple organs,influenced by genetic factors,especially those related to the immune system.However,there is a need for new biomar...
关键词：Systemic lupus erythematosus microRNA-125a INTERLEUKIN-12 Tumor necrosis factor alpha BIOMARKER 
MEF2C promotes M1 macrophage polarization and Th1 responses被引量：9
《Cellular & Molecular Immunology》2022年第4期540-553,共14页Xibao Zhao Qianqian Di Han Liu Jiazheng Quan Jing Ling Zizhao Zhao Yue Xiao Han Wu Zherui Wu Wengang Song Huazhang An Weilin Chen 
This work was supported by grants from the National Key Research and Development Program of China(2016YFA0502201)awarded to Prof.Huazhang An;the National Natural Science Foundation of China(Nos.U1801283,31870908);the Guangdong Provincial Science and Technology Program(No.2019B030301009);the SZU Top Ranking Project(No.86000000210)awarded to Prof.Weilin Chen;the National Natural Science Foundation of China(No.81771711)awarded to Prof.Wengang Song;the Guangdong Provincial Science and Technology Program(No.2019A1515110086)awarded to Xibao Zhao.We thank Jessica Kate Tamanini(Scientific Editor,Shenzhen University School of Medicine)for editing the manuscript.
The polarization of macrophages to the M1 or M2 phenotype has a pivotal role in inflammation and host defense;however,the underlying molecular mechanism remains unclear.Here,we show that myocyte enhancer factor 2 C(ME...
关键词：Myocyte enhancer factor 2C Macrophage polarization INTERLEUKIN-12 T helper type 1 response Inflammation 
New era of electrochemotherapy in treatment of liver tumors in conjunction with immunotherapies
《World Journal of Gastroenterology》2021年第48期8216-8226,共11页BlažTrotovšek Mihajlo Djokić MajaČemažar Gregor Serša 
Supported by the Slovenian Research Agency (ARRS)(P3-0003);cofinanced by the Republic of Slovenia and the European Regional Development Fund (Project Smart Gene.Si)。
Electrochemotherapy is a local ablative therapy that increases the cytotoxicity of either bleomycin or cisplatin by applying electric pulses(electroporation)to tumors.It has already been widely used throughout Europe ...
关键词：ELECTROPORATION ELECTROCHEMOTHERAPY Gene therapy Gene electrotransfer INTERLEUKIN-12 Immune checkpoint inhibitors Hepatocellular carcinoma 
Transdermal delivery of interleukin-12 gene targeting dendritic cells enhances the anti-tumour effect of programmed cell death protein 1 monoclonal antibody被引量：1
《Biomaterials Translational》2021年第2期151-164,共14页Huoyan Hong Xiaoyun Wang Xinran Song Gomaa El Fawal Kaili Wang Di Jiang Yifei Pei Zhe Wang Hongsheng Wang 
supported by the Science&Technology Commission of Shanghai Municipality of China,Nos.18490740400,20DZ2254900;the National Key Research&Development Program of China,No.2018YFC1706200.
Recent studies have suggested that the anti-tumour effect of the programmed cell death protein 1 monoclonal antibody(aPD-1)depends on the expression of interleukin-12(IL-12)by dendritic cells(DCs).Since DCs are abunda...
关键词：aPD-1 dendritic cells ethosome IL-12 transcutaneous immunization 
Interleukin-12 supports in vitro self-renewal of long-term hematopoietic stem cells
《Blood Science》2019年第1期92-101,共10页Shanshan Zhang Maiko Morita Zhao Wang Jun Ooehara Sen Zhang Miner Xie Haitao Bai Wenying Yu Xiaofang Wang Fang Dong Jinhong Wang Shihui Ma Satoshi Yamazaki Hideo Ema 
supported by grants from the National Key Research and Development Program of China Stem Cell and Translational Research(2017YFA0104903,2016YFA0100600,and 2017YFA0103400);the Ministry of Science and Technology of China(2015CB964403 and,2011CB964801);the CAMS Initiative for Innovative Medicine(2016-I2M-1-017 and 2017-I2M-1-015);the National Natural Science Foundation of China(81470279,81670105,81421002,81400077,and 81500085).
Hematopoietic stem cells(HSCs)self-renew or differentiate through division.Cytokines are essential for inducing HSC division,but the optimal cytokine combination to control self-renewal of HSC in vitro remains unclear...
关键词：Ex vivo expansion Hematopoietic stem cells INTERLEUKIN-12 SELF-RENEWAL 
Moderating effect of synthesized docosahexaenoic acid-enriched phosphatidylcholine on production of Th1 and Th2 cytokine in lipopolysaccharide-induced inflammation被引量：2
《Asian Pacific Journal of Tropical Biomedicine》2018年第7期340-344,共5页M.Choi JY.Baek I.Park SY.Lim 
supported by Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Science,ICT and Future Planning(NRF-2017R1A2B4005915)
Objective: To evaluate effects of docosahexaenoic acid-enriched phosphatidylcholine(DHAPC) on cytokine production induced by lipopolysaccharide(LPS). Methods: The culture supernatants of splenocytes exposed to DHA-PC ...
关键词：Docosahexaenoic acid PHOSPHATIDYLCHOLINE Cytokines INTERLEUKIN-2 INTERLEUKIN-6 Interleukin-12/IL-23(p40) 
Interleukin-12 and interferon-γacting on damp-heat of spleen-stomach syndrome triggered by helicobacter pylori被引量：7
《Journal of Traditional Chinese Medicine》2017年第6期827-834,共8页Chen Wanqun Hu Ling Li Heyuan Luo Qi Fan Dongmei Zhang Yunzhan 
Supported by Natural Science Foundation-funded Project:Research on the NF-KB Pathway and Micro-ecology Alteration Based on Helicobacter Pylori Correlated Gastric Disease(No.30772689);Natural Science Foundation-funded Project:Progression of Diverse Syndromes on Mi RNAs and Gene Polymorphism of Inflammatory Cytokines in Helicobacter Pylori Correlated Gastric Disease Based on Pathogenic Toxin(No.81373563)
OBJECTIVE: To investigate the expression of and interleukin-12(IL-12) and interferon-γ(IFN-γ) in relation to the pathology of damp-heat of spleen-stomach syndrome(DHSS) induced by Helicobacter pylori(H. pylori) infe...
关键词：Helicobacter pylori INTERLEUKIN-12 INTERFERON-GAMMA Spleen stomach dampness heat Spleen Qi deficiency 
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