DETOXIFYING　EFFECT　OF　LISHENG－SE　ON　CDDP　AND　ITS　RELATION　TO　METALLOTHIONEIN　INDUCTION  

作　　者：徐卓立 郭军华 宋三泰 卢淑娟 吴德政 

出　　处：《Chinese Journal of Cancer Research》1995年第4期239-242,共4页中国癌症研究（英文版）

摘　　要：The effects of Lisheng-Se (Seleninized wheat germ)on metollothionein (MT) induction, lethal systemic toxicity, hemotoxicity and anticancer activity of cisplatin (CDDP), were investigated in mice. The systemic toxicity of CDDP was signiftcantly reduced by preadministration of Lisheng-Se (P<0.05 or P<0.01). The protective effects were better than its inorganic form (Na2 SeO3) and Bi (BSN), (0.05<P<0.1). The MT level in the liver, kidney and tumor tissues of mice treated with one of those compounds was determined. The liver and kidney (P<0.01and P<0.05). It was just in conformity with the conclusion that the best Protective effect appeared in the groups treated with Lisheng-Se. These result suggest that Increased MT synthesis in the liver and kidney may be involved in the protective effects of Lashing-Se tested on the lethal toxicity, nephrotoxicity and hemotoxicity produced by CDDP. The experiments also showed thatLisheng-Se did not affect the anticancer activity of CDDP in vitro and in vivo, while the MT level was not increased in cancer (p>0.05), so Lisheng-Se might not only improve the therapeutic index of CDDP, but also did not cause drug-resistance of cancer cells.The effects of Lisheng-Se (Seleninized wheat germ)on metollothionein (MT) induction, lethal systemic toxicity, hemotoxicity and anticancer activity of cisplatin (CDDP), were investigated in mice. The systemic toxicity of CDDP was signiftcantly reduced by preadministration of Lisheng-Se (P<0.05 or P<0.01). The protective effects were better than its inorganic form (Na2 SeO3) and Bi (BSN), (0.05<P<0.1). The MT level in the liver, kidney and tumor tissues of mice treated with one of those compounds was determined. The liver and kidney (P<0.01and P<0.05). It was just in conformity with the conclusion that the best Protective effect appeared in the groups treated with Lisheng-Se. These result suggest that Increased MT synthesis in the liver and kidney may be involved in the protective effects of Lashing-Se tested on the lethal toxicity, nephrotoxicity and hemotoxicity produced by CDDP. The experiments also showed thatLisheng-Se did not affect the anticancer activity of CDDP in vitro and in vivo, while the MT level was not increased in cancer (p>0.05), so Lisheng-Se might not only improve the therapeutic index of CDDP, but also did not cause drug-resistance of cancer cells.

关 键 词：Se/Pharmacology CDDP/Toxicity  Metallothionein 

分 类 号：R730.2[医药卫生—肿瘤]