THE　COMPARISON　STUDY　OF　ESTABLISHING　ANIMAL　MODEL　OF　HUMAN　UTERINE　CANCERUSING　MATRIGEL  

作　　者：邓小虹 

出　　处：《Chinese Journal of Cancer Research》1995年第3期168-171,共4页中国癌症研究（英文版）

摘　　要：The human endometrial adenocarcinoma cell liueIskikawa cells suspended either in Matrigel or MEM buffer medium were injected subcutaneously to nude mice (N=10 mice/group);and the fresh human cervical cancer tissues obtained directly from the surgery were coated by Matrigel and transplanted into nude mouse. The purpose of these studies were to see if Matrigel could enhance the human uteriue cancers' proliferation and differentiation in vivo.The results showed that when cancer cells or tissues implanted into nude mice in Matrigel, the xenografts could turn out earlier, proliferate faster and kept the original differentiation better.It is suggested that Matrigel is an ideal agent in establishing animal models of human uterine cancer.The human endometrial adenocarcinoma cell liueIskikawa cells suspended either in Matrigel or MEM buffer medium were injected subcutaneously to nude mice (N=10 mice/group);and the fresh human cervical cancer tissues obtained directly from the surgery were coated by Matrigel and transplanted into nude mouse. The purpose of these studies were to see if Matrigel could enhance the human uteriue cancers' proliferation and differentiation in vivo.The results showed that when cancer cells or tissues implanted into nude mice in Matrigel, the xenografts could turn out earlier, proliferate faster and kept the original differentiation better.It is suggested that Matrigel is an ideal agent in establishing animal models of human uterine cancer.

关 键 词：MATRIGEL Endometrium cancer cell IMPLANTATION Nude mouse Cervical cancer. 

分 类 号：R737.33[医药卫生—肿瘤]