COMPARATIVE　PATHOLOGICAL　AND　FCM　STUDIES　ON　THE　PRIMARY　AND　METASTATIC　CANCERS　IN　STOMACH　AND　BREAST  

作　　者：张祥宏 张杰英 谢同欣 王俊灵 严霞 路灵敏 王进 左连富 王风荣 

出　　处：《Chinese Journal of Cancer Research》1995年第1期55-60,共6页中国癌症研究（英文版）

摘　　要：Pathological morphology,differentiation,cellular DNA content and cell Proliferation index(PI) were comparatively studied in the primary and their corresponding metastatic lesions of 54 cases of gastric and breast cancers- The results showed that differentiation and types of metastatic cancers were in accordance with their corresponding primary cancers in more than half cases(18/13) of stomach cancers,differences could be found in the other cases(16/34),and among them,10 were lower and 6 were higher differentially than their corresponding primary cancers.Similar results were found in breast cancer cases.Flow cytometry(FCM) analysis revealed that dramatic DNA Index(DI) differences between metastatic and their corresponding primary cancers existed in 6/34 of gastric and 4/18 of mammary cancers,among them 7 cases were higher than the primary while 3 were lower than the primary(DI).Similar results could also be found in PI analysis.All these suggested that metastasis of gastric and breast cancer was a very complicated process and metastatic cancer did not necessarily always show lower differentiation,higher DNA contents and DNA aneuploidy as well as higher cell proliferative rate.Pathological morphology,differentiation,cellular DNA content and cell Proliferation index(PI) were comparatively studied in the primary and their corresponding metastatic lesions of 54 cases of gastric and breast cancers- The results showed that differentiation and types of metastatic cancers were in accordance with their corresponding primary cancers in more than half cases(18/13) of stomach cancers,differences could be found in the other cases(16/34),and among them,10 were lower and 6 were higher differentially than their corresponding primary cancers.Similar results were found in breast cancer cases.Flow cytometry(FCM) analysis revealed that dramatic DNA Index(DI) differences between metastatic and their corresponding primary cancers existed in 6/34 of gastric and 4/18 of mammary cancers,among them 7 cases were higher than the primary while 3 were lower than the primary(DI).Similar results could also be found in PI analysis.All these suggested that metastasis of gastric and breast cancer was a very complicated process and metastatic cancer did not necessarily always show lower differentiation,higher DNA contents and DNA aneuploidy as well as higher cell proliferative rate.

关 键 词：Gastric carcinoma Breast carcinoma Metastasis Differentiation FCM DNA index Proliferation index. 

分 类 号：R735[医药卫生—肿瘤]