The Prevenlive-Therapeutic Effects of Reduqing (热毒清)on Endotoxin-Induced DIC in Rabbits (Continued)Protection of Hepatocytic Microsomes, Maintenance of CalciumHomeostasis and Reduction of Oxygen Free Radicals  

作　　者：李鸣真 叶望云 涂胜豪 侯安继 邓泽民 陆付耳 王开富 林宝英 

机构地区：[1]Institute of Integrated Traditional Chinese Medicine andWestern Medicine, Tongji Medical University.Wuhan(430030)

出　　处：《Chinese Journal of Integrative Medicine》1995年第3期223-226,共4页中国结合医学杂志（英文版）

摘　　要：Disseminated intravascular coagulation (DIC) model of rabbits was made by the injectionof endotoxin. Cytochrome P-450 content and aniline hydroxylase activity in hepatocytic microsomes in DICrabbits were significantly reduced. The microviscosity of mitochondrial membrane was elevated, whilethe fluidity of the membrane, and the activities of calcium-magnesium-adenosine triphosphatase and calci-um-adenosine triphosphatase were reduced. Lipid peroxide and xanthine oxidase activities were in-creased. while superoxide dismutase and glutathione peroxidase activities were significantly decreased(P<0.05 or <0. 01) . The changes in the Reduqing test group were not prominent. and the parameters ofthe test group were close to those of the control group. This study suggests that in endotoxin induced DICrabbits the hepatocytic microsomes are injured. calcium homeostasis is disturbed and oxygen free radicalsare notably accumulated. Whereas Reduqing may have a protective effect on hepatocytic microsomestrom the injury, maintain calcium homeostasis and reduce oxygen free radicals in DIC rabbits.Disseminated intravascular coagulation (DIC) model of rabbits was made by the injectionof endotoxin. Cytochrome P-450 content and aniline hydroxylase activity in hepatocytic microsomes in DICrabbits were significantly reduced. The microviscosity of mitochondrial membrane was elevated, whilethe fluidity of the membrane, and the activities of calcium-magnesium-adenosine triphosphatase and calci-um-adenosine triphosphatase were reduced. Lipid peroxide and xanthine oxidase activities were in-creased. while superoxide dismutase and glutathione peroxidase activities were significantly decreased(P<0.05 or <0. 01) . The changes in the Reduqing test group were not prominent. and the parameters ofthe test group were close to those of the control group. This study suggests that in endotoxin induced DICrabbits the hepatocytic microsomes are injured. calcium homeostasis is disturbed and oxygen free radicalsare notably accumulated. Whereas Reduqing may have a protective effect on hepatocytic microsomestrom the injury, maintain calcium homeostasis and reduce oxygen free radicals in DIC rabbits.

关 键 词：REDUQING ENDOTOXIN MICROSOME calcium homeostasis oxygen free radicals 

分 类 号：R285.5[医药卫生—中药学]